The role of the hippocampus in object discrimination based on visual features
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29886092
DOI
10.1016/j.nlm.2018.06.003
PII: S1074-7427(18)30140-0
Knihovny.cz E-resources
- Keywords
- Hippocampus, Muscimol, Object discrimination, Operant conditioning, Visual discrimination,
- MeSH
- GABA-A Receptor Agonists pharmacology MeSH
- Behavior, Animal drug effects physiology MeSH
- Discrimination Learning drug effects physiology MeSH
- Generalization, Psychological drug effects physiology MeSH
- Hippocampus drug effects physiology MeSH
- Rats MeSH
- Muscimol pharmacology MeSH
- Conditioning, Operant drug effects physiology MeSH
- Rats, Long-Evans MeSH
- Pattern Recognition, Visual drug effects physiology MeSH
- Form Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- GABA-A Receptor Agonists MeSH
- Muscimol MeSH
The role of rodent hippocampus has been intensively studied in different cognitive tasks. However, its role in discrimination of objects remains controversial due to conflicting findings. We tested whether the number and type of features available for the identification of objects might affect the strategy (hippocampal-independent vs. hippocampal-dependent) that rats adopt to solve object discrimination tasks. We trained rats to discriminate 2D visual objects presented on a computer screen. The objects were defined either by their shape only or by multiple-features (a combination of filling pattern and brightness in addition to the shape). Our data showed that objects displayed as simple geometric shapes are not discriminated by trained rats after their hippocampi had been bilaterally inactivated by the GABAA-agonist muscimol. On the other hand, objects containing a specific combination of non-geometric features in addition to the shape are discriminated even without the hippocampus. Our results suggest that the involvement of the hippocampus in visual object discrimination depends on the abundance of object's features.
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