Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study
Language English Country Japan Media print-electronic
Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
PubMed
30027443
DOI
10.1007/s00540-018-2532-6
PII: 10.1007/s00540-018-2532-6
Knihovny.cz E-resources
- Keywords
- Anesthesia induction, General anesthesia, Hypotension, Predictors, Risk factors,
- MeSH
- Anesthetics, Intravenous administration & dosage adverse effects MeSH
- Arterial Pressure drug effects MeSH
- Anesthesia, General adverse effects methods MeSH
- Adult MeSH
- Hypertension epidemiology MeSH
- Hypotension epidemiology MeSH
- Intubation, Intratracheal MeSH
- Blood Pressure drug effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Blood Pressure Determination MeSH
- Propofol administration & dosage pharmacology MeSH
- Prospective Studies MeSH
- Cross-Sectional Studies MeSH
- Risk Factors MeSH
- Aged MeSH
- Sufentanil administration & dosage pharmacology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anesthetics, Intravenous MeSH
- Propofol MeSH
- Sufentanil MeSH
BACKGROUND: Hypotension after induction of general anesthesia (GAIH) is common in anesthesiology practice and can impact outcomes. METHODS: In this prospective multicenter, cross-sectional, observational study, the hypotension was defined as a decrease in mean arterial pressure of > 30% compared to the first measurement in the operation theatre before general anesthesia (GA) induction. Blood pressure was measured immediately at the time of endotracheal intubation (TETI), at five (T5) and 10 (T10) minutes after. All subjects aged > 18 years undergoing elective non-cardiac surgery under GA were included. The goals were description of GAIH occurrence, the association of GAIH with selected comorbidities, chronic medications, and anesthetics with GAIH, and the type and efficacy of interventions used to correct hypotension. RESULTS: Data from 661 subjects, whose GA was induced with propofol and sufentanil, were analyzed. In 36.5% of subjects, GAIH was observed at ≥ 1 of the assessed time points. GAIH was present in 2.9% subjects at all time points. The probability of GAIH is raising with age, degree of hypertension at time of arrival to theatre and presence of diabetes. The type of volatile anesthetic was not associated with the occurrence of GAIH. The overall efficiency of interventions to correct hypotension was 94.4%. Bolus fluids were the most often used intervention and was 96.4% effective. CONCLUSION: GAIH rate depends on age, degree of blood pressure decompensation prior the surgery, and presence of diabetes mellitus type II.
Department of Anesthesia and Resuscitation Novy Jicin Hospital Novy Jicin Czech Republic
Department of Applied Mathematics Technical University of Ostrava Ostrava Czech Republic
Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czech Republic
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