Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient
Language English Country Canada Media print-electronic
Document type Case Reports, Journal Article
PubMed
30063985
DOI
10.1016/j.ijid.2018.07.021
PII: S1201-9712(18)34482-5
Knihovny.cz E-resources
- Keywords
- Enterocytozoon bieneusi, Hematopoietic stem cell transplant, Respiratory tract infection,
- MeSH
- Albendazole therapeutic use MeSH
- Bronchoalveolar Lavage MeSH
- Enterocytozoon drug effects isolation & purification MeSH
- HIV Infections MeSH
- Immunocompromised Host drug effects MeSH
- Urinary Tract Infections diagnosis drug therapy MeSH
- Levofloxacin therapeutic use MeSH
- Humans MeSH
- Microsporidiosis diagnosis drug therapy MeSH
- Young Adult MeSH
- Risk Factors MeSH
- Hematopoietic Stem Cell Transplantation * MeSH
- Check Tag
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Albendazole MeSH
- Levofloxacin MeSH
A 23-year-old, HIV-negative woman who had undergone a hematopoietic stem cell transplantation was admitted to the hospital with respiratory failure and symptoms of bronchiolitis obliterans. A chest computed tomography scan revealed diffuse ground-glass opacification and fibrous plugs. Due to worsening respiratory failure despite treatment, ventilation was provided through a tracheostomy tube. Molecular examination of bronchoalveolar lavage and urine revealed Enterocytozoon bieneusi infection. After treatment with albendazole the patient gradually improved, but the pathogen was not eradicated and reappeared on follow-up examination. E. bieneusi belongs to the most clinically important microsporidial species infecting humans, mostly those who are immunocompromised. This fungus tends to infect enterocytes of the intestine, and there are limited studies concerning its extraintestinal location. This is the first report of a case of disseminated respiratory and urinary E. bieneusi infection in a transplant recipient.
Department of Biology and Medical Parasitology Wroclaw Medical University Wroclaw Poland
Lower Silesian Center for Cellular Transplantations Wroclaw Poland
References provided by Crossref.org
Chronic Infections in Mammals Due to Microsporidia
