Long-Term Prognosis of Patients With Takotsubo Syndrome
Language English Country United States Media print
Document type Journal Article, Observational Study
PubMed
30115226
DOI
10.1016/j.jacc.2018.06.016
PII: S0735-1097(18)35270-7
Knihovny.cz E-resources
- Keywords
- Takotsubo syndrome, acute coronary syndrome, broken heart syndrome, classification, outcome, stress factor,
- MeSH
- Acute Coronary Syndrome diagnosis mortality physiopathology MeSH
- Time Factors MeSH
- Electroencephalography mortality trends MeSH
- Middle Aged MeSH
- Humans MeSH
- Mortality trends MeSH
- Follow-Up Studies MeSH
- Nervous System Diseases diagnosis physiopathology MeSH
- Prognosis MeSH
- Stress, Psychological diagnosis mortality physiopathology MeSH
- Registries * MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Takotsubo Cardiomyopathy diagnosis mortality physiopathology psychology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
BACKGROUND: Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive. OBJECTIVES: This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers. METHODS: Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions. RESULTS: Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients. CONCLUSIONS: Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (International Takotsubo Registry [InterTAK Registry]; NCT01947621).
1st Department of Cardiology Medical University of Gdansk Gdansk Poland
Cardiology 1 Center for Cardiology University Medical Center Mainz Mainz Germany
Charles University Prague and University Hospital Kralovske Vinohrady Prague Czech Republic
Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany
Department of Cardiology and Angiology Hannover Medical School Hannover Germany
Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France
Department of Cardiology Charité Campus Rudolf Virchow Berlin Germany
Department of Cardiology Heidelberg University Hospital Heidelberg Germany
Department of Cardiology John Radcliffe Hospital Oxford University Hospitals Oxford United Kingdom
Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland
Department of Cardiology Kantonsspital Winterthur Winterthur Switzerland
Department of Cardiology Kings College Hospital Kings Health Partners London United Kingdom
Department of Cardiology Leiden University Medical Centre Leiden the Netherlands
Department of Cardiology Medical University of Warsaw Warsaw Poland
Department of Cardiology University Hospital Basel Basel Switzerland
Department of Cardiovascular Sciences Catholic University of the Sacred Heart Rome Rome Italy
Department of Internal Medicine 2 Cardiology University of Ulm Medical Center Ulm Germany
Department of Internal Medicine 3 Heart Center University of Cologne Cologne Germany
Department of Mathematics and Computer Science University of Bremen Bremen Germany
Department of Medicine College of Medicine University of Florida Gainesville Florida
Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota
Heart and Vascular Centre Bad Bevensen Bad Bevensen Germany
Heart Center Leipzig University Hospital Department of Internal Medicine Cardiology Leipzig Germany
Heart Center Turku University Hospital and University of Turku Turku Finland
Heart Department University Hospital San Giovanni di Dio e Ruggi d'Aragona Salerno Italy
Intensive Coronary Care Unit Moscow City Hospital 1 named after N Pirogov Moscow Russia
Internal Medicine Cardiology Angiology and Pneumology Magdeburg University Magdeburg Germany
Klinik für Innere Medizin 3 Universitätsklinikum des Saarlandes Homburg Saar Germany
Krankenhaus Maria Hilf Medizinische Klinik Stadtlohne Germany
TJ Health Partners Heart and Vascular Glasgow Kentucky
University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland
University Hospital for Internal Medicine 3 Medical University Innsbruck Innsbruck Austria
University of Southern California Keck School of Medicine Los Angeles California
References provided by Crossref.org
Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review
ClinicalTrials.gov
NCT01947621
