The history of poisoning is one of the greatest chapters of the human history, where curiosity and genius, scientific discoveries and empirical knowledge intertwine with intrigues, crimes, politics, personal tragedies of notabilities, wars and natural disasters. Knowledge of toxic substances is likely as old as the mankind. In the Middle Age, Paracelsus claimed that in the world there is no non-toxic substance that the therapeutic and toxic properties of substances are indistinguishable up to a single parameter-dose. This postulate still belongs among the basic pillars of modern toxicology. Probably, the most ancient way of killing people was poisoning. In addition, the presence of poison in the body of the victim was very difficult to determine, since the symptoms of poisoning were similar to signs of certain diseases. Therefore, the criminals had a big chance to escape the punishment. Nowadays, together with development of toxicology the chance of disclosure of such crimes has increased, however, the progress in the field of design and production of toxic substances has also gone up. Within current contribution we have reviewed the most famous historical cases of poisoning from the antiquity to the present.

Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanskeho 62 500 03 Hradec Kralove Czech Republic

Faculty of Philosophy University of Hradec Kralove Rokitanskeho 62 500 03 Hradec Kralove Czech Republic

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Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention

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