Investigation of melanoma-associated antigen A4 cancer/testis antigen clinical relevance in esophageal squamous cell carcinoma
Language English Country India Media print
Document type Journal Article
PubMed
30197348
DOI
10.4103/0973-1482.183180
PII: JCanResTher_2018_14_5_1059_183180
Knihovny.cz E-resources
- Keywords
- Cancer-testis antigens, esophageal squamous cell carcinoma, immunohistochemistry, melanoma-associated antigen A4, tumor marker,
- MeSH
- Antigens, Neoplasm genetics MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphatic Metastasis genetics pathology MeSH
- Biomarkers, Tumor genetics MeSH
- Neoplasm Proteins genetics MeSH
- Esophageal Neoplasms genetics pathology MeSH
- Disease-Free Survival MeSH
- Prognosis * MeSH
- Gene Expression Regulation, Neoplastic genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Esophageal Squamous Cell Carcinoma MeSH
- Carcinoma, Squamous Cell genetics pathology MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antigens, Neoplasm MeSH
- MAGEA4 protein, human MeSH Browser
- Biomarkers, Tumor MeSH
- Neoplasm Proteins MeSH
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment. MATERIALS AND METHODS: Fifty-six ESCC patients with no preoperative therapeutic circumstance such as radiotherapy or chemotherapy were analyzed to explore the protein expression level of MAGEA4 using immunohistochemistry assay. RESULTS: MAGEA4 overexpression was detected in 66% of ESCC samples showing strong nuclear and cytoplasmic staining compared to the normal epithelium. There were significant correlations between MAGEA4 protein expression and depth of tumor invasion (P = 0.019), and the number of involved lymph nodes (P = 0.045). CONCLUSION: Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in ESCC aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness.
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