EEG correlates of induced anxiety in obsessive-compulsive patients: comparison of autobiographical and general anxiety scenarios

. 2018 ; 14 () : 2165-2174. [epub] 20180827

Status PubMed-not-MEDLINE Jazyk angličtina Země Nový Zéland Médium electronic-ecollection

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid30214206

BACKGROUND: The underlying symptomatology of obsessive-compulsive disorder (OCD) can be viewed as an impairment in both cognitive and behavioral inhibition, regarding difficult inhibition of obsessions and behavioral compulsions. Converging results from neuroimaging and electroencephalographic (EEG) studies have identified changes in activities throughout the medial frontal and orbital cortex and subcortical structures supporting the cortico-striato-thalamo-cortical circuit model of OCD. This study aimed to elucidate the electrophysiological changes induced by autobiographical and general anxiety scenarios in patients with OCD. METHODS: Resting-state eyes-closed EEG data were recorded in 19 OCD patients and 15 healthy controls. Cortical EEG sources were estimated by standardized low-resolution electromagnetic tomography (sLORETA). The changes in the emotional state were induced by two different scenarios: the autobiographical script related to patient's OCD symptoms and the script triggering general anxiety. RESULTS: During the resting state, we proved increased delta activity in the frontal, limbic and temporal lobe and the sub-lobar area in OCD patients. In a comparison of neural activities during general anxiety in OCD patients and the control group, we proved an increase in delta (parietal, temporal, occipital, frontal and limbic lobes, and sub-lobal area), theta (temporal, parietal and occipital lobes) and alpha-1 activities (parietal lobe). Finally, we explored the neural activity of OCD patients during exposure to the autobiographic scenario. We proved an increase in beta-3 activity (left frontal lobe). CONCLUSION: Our study proved differences in neural activation in OCD patients and healthy controls during imagination of general anxiety. Exposure to the autobiographic OCD scenario leads to activation of left frontal brain areas. The results show the possibility of using specific scenarios in OCD therapy.

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World Health Organisation (WHO) ICD-10: TheICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organisation (WHO); 1992.

American Psychiatric Association . Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.

Salkovskis PM, Harrison J. Abnormal and normal obsessions: a replication. Behav Res Ther. 1984;22(5):549–552. PubMed

Bannon S, Gonsalvez CJ, Croft RJ, Boyce PM. Response inhibition deficits in obsessive-compulsive disorder. Psychiatry Res. 2002;110(2):165–174. PubMed

Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev. 2005;29(3):399–419. PubMed

Herrmann MJ, Jacob C, Unterecker S, Fallgatter AJ. Reduced response-inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Res. 2003;120(3):265–271. PubMed

Aouizerate B, Guehl D, Cuny E, et al. Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol. 2004;72(3):195–221. PubMed

Wood J, Ahmari SE. A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors. Front Syst Neurosci. 2015;9:171. PubMed PMC

Milad MR, Rauch SL. Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn Sci. 2012;16(1):43–51. PubMed PMC

Ullsperger M, von Cramon DY. The role of intact frontostriatal circuits in error processing. J Cogn Neurosci. 2006;18(4):651–664. PubMed

Nakao T, Okada K, Kanba S. Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neu-roimaging findings. Psychiatry Clin Neurosci. 2014;68(8):587–605. PubMed

Remijnse PL, Nielen MM, van Balkom AJ, et al. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry. 2006;63(11):1225–1236. PubMed

Marsh R, Tau GZ, Wang Z, et al. Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. Am J Psychiatry. 2015;172(4):383–392. PubMed PMC

Gu BM, Park JY, Kang DH, et al. Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder. Brain. 2008;131(Pt 1):155–164. PubMed

Fineberg NA, Chamberlain SR, Hollander E, Boulougouris V, Robbins TW. Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment. Br J Pharmacol. 2011;164(4):1044–1061. PubMed PMC

Roth RM, Saykin AJ, Flashman LA, Pixley HS, West JD, Mamourian AC. Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biol Psychiatry. 2007;62(8):901–909. PubMed

Demeter G, Racsmány M, Csigó K, Harsányi A, Németh A, Döme L. Intact short-term memory and impaired executive functions in obsessive compulsive disorder. Ideggyogy Sz. 2013;66(1–2):35–41. PubMed

Karadag F, Oguzhanoglu NK, Kurt T, Oguzhanoglu A, Ateşci F, Ozdel O. Quantitative EEG analysis in obsessive compulsive disorder. Int J Neurosci. 2003;113(6):833–847. PubMed

Sherlin L, Congedo M. Obsessive-compulsive dimension localized using low-resolution brain electromagnetic tomography (LORETA) Neurosci Lett. 2005;387(2):72–74. PubMed

Pogarell O, Juckel G, Mavrogiorgou P, et al. Symptom-specific EEG power correlations in patients with obsessive-compulsive disorder. Int J Psychophysiol. 2006;62(1):87–92. PubMed

Velikova S, Locatelli M, Insacco C, Smeraldi E, Comi G, Leocani L. Dysfunctional brain circuitry in obsessive-compulsive disorder: source and coherence analysis of EEG rhythms. Neuroimage. 2010;49(1):977–983. PubMed

Kopřivová J, Congedo M, Horáček J, et al. EEG source analysis in obsessive-compulsive disorder. Clin Neurophysiol. 2011;122(9):1735–1743. PubMed

Kopřivová J, Horáček J, Raszka M, Brunovský M, Praško J. Standardized low-resolution electromagnetic tomography in obsessive-compulsive disorder – a replication study. Neurosci Lett. 2013;548:185–189. PubMed

Krause D, Folkerts M, Karch S, et al. Prediction of treatment outcome in patients with obsessive-compulsive disorder with low-resolution brain electromagnetic tomography: a prospective EEG Study. Front Psychol. 2015;6:1993. PubMed PMC

Sponheim SR, Clementz BA, Iacono WG, Beiser M. Clinical and biological concomitants of resting state EEG power abnormalities in schizophrenia. Biol Psychiatry. 2000;48(11):1088–1097. PubMed

Lavoie S, Schäfer MR, Whitford TJ, et al. Frontal delta power associated with negative symptoms in ultra-high risk individuals who transitioned to psychosis. Schizophr Res. 2012;138(2–3):206–211. PubMed

Leuchter AF, Cook IA, Hunter AM, Cai C, Horvath S. Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression. PLoS One. 2012;7(2):e32508. PubMed PMC

Meerwijk EL, Ford JM, Weiss SJ. Resting-state EEG delta power is associated with psychological pain in adults with a history of depression. Biol Psychol. 2015;105:106–114. PubMed PMC

Sachs G, Anderer P, Dantendorfer K, Saletu B. EEG mapping in patients with social phobia. Psychiatry Res. 2004;131(3):237–247. PubMed

Bandelow B, Zohar J, Hollander E, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders – first revision. World J Biol Psychiatry. 2008;9(4):248–312. PubMed

Graybiel AM, Rauch SL. Toward a neurobiology of obsessive- compulsive disorder. Neuron. 2000;28(2):343–347. PubMed

Stein DJ, Fineberg NA, Bienvenu OJ, et al. Should OCD be classified as an anxiety disorder in DSM-V? Depress Anxiety. 2010;27(6):495–506. PubMed

Brewer D, Doughtie EB. Induction of mood and mood shift. J Clin Psychol. 1980;36(1):215–226. PubMed

Abele A. Recall of positive and negative life events. Studies of mood-inducing effect and production of texts. Z Exp Angew Psychol. 1990;37(2):181–207. PubMed

Prasko J, Mozny P, Slepecky M. Kognitivne behavioralni terapie psychickych poruch. Triton. 2007

Abramowitz JS. Variants of exposure and response prevention in the treatment of obsessive-compulsive disorder: a meta-analysis. Behav Ther. 1996;27(4):583–600.

Gillihan SJ, Williams MT, Malcoun E, Yadin E, Foa EB. Common pitfalls in exposure and response prevention (EX/RP) for OCD. J Obsessive Compuls Relat Disord. 2012;1(4):251–257. PubMed PMC

Pitman RK, Orr SP, Forgue DF, de Jong JB, Claiborn JM. Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans. Arch Gen Psychiatry. 1987;44(11):970–975. PubMed

Bond CVA. Personal relevance is an important dimension for visceral reactivity in emotional imagery. Cognition & Emotion. 1998;12(2):231–242.

Admon R, Bleich-Cohen M, Weizmant R, Poyurovsky M, Faragian S, Hendler T. Functional and structural neural indices of risk aversion in obsessive-compulsive disorder (OCD) Psychiatry Res. 2012;203(2–3):207–213. PubMed

van den Heuvel OA, Veltman DJ, Groenewegen HJ, et al. Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry. 2005;62(8):922–933. PubMed

Thomas SJ, Gonsalvez CJ, Johnstone SJ. Neural time course of threat-related attentional bias and interference in panic and obsessive-compulsive disorders. Biol Psychol. 2013;94(1):116–129. PubMed

EMEA COMMISSION DIRECTIVE 2005/28/EC of 8 April 2005. Laying down principles and detailed guidelines for good clinical practice as regards investigational medicinal products for human use, as well as the requirements for authorisation of the manufacturing or importation of such products. [Accessed August 13, 2018]. Available from: https://ec.europa.eu/health//sites/health/files/files/eudralex/vol-1/dir_2005_28/dir_2005_28_en.pdf.

Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33. PubMed

Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893–897. PubMed

Hamilton MC, Schutte NS, Malouff JM. Hamilton anxiety scale (HAMA) Sourcebook of Adult Assessment (Applied Clinical Psychology) 1976:154–157.

Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–571. PubMed

Preiss M, Vaclíř K. Beckova sebeposuzující škála depresivity pro dospělé BDI-II, příručka. Psychodiagnostika; Brno: 1999.

Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62. PubMed PMC

Goodman WK, Rasmussen SA, Price LH. Yale-Brown Obsessive- Compulsive Scale (Y-BOCS) New Haven, CT: Yale University, Department of Psychiatry; 1986.

Kubicki S, Herrmann WM, Fichte K, Freund G. Reflections on the topics: EEG frequency bands and regulation of vigilance. Pharmakopsychiatr Neuropsychopharmakol. 1979;12(2):237–245. PubMed

Pascual-Marqui RD. Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol. 2002;24(Suppl D):5–12. PubMed

Holmes AP, Blair RC, Watson JD, Ford I. Nonparametric analysis of statistic images from functional mapping experiments. J Cereb Blood Flow Metab. 1996;16(1):7–22. PubMed

Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. Stuttgart: Thieme; 1988.

Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32(1):50–55. PubMed

Kamarádová D, Prasko J, Latalova K, et al. Psychometric properties of the Czech version of the Beck Anxiety Inventory – comparison between diagnostic groups. Neuro Endocrinol Lett. 2015;36(7):706–712. PubMed

Mckay D, Danyko S, Neziroglu F, Yaryura-Tobias JA. Factor structure of the Yale-Brown Obsessive-Compulsive Scale: a two dimensional measure. Behav Res Ther. 1995;33(7):865–869. PubMed

O’Connor KP, Aardema F, Robillard S, et al. Cognitive behaviour therapy and medication in the treatment of obsessive-compulsive disorder. Acta Psychiatr Scand. 2006;113(5):408–419. PubMed

Buzsáki G. Theta oscillations in the hippocampus. Neuron. 2002;33(3):325–340. PubMed

Başar-Eroğlu C, Başar E, Demiralp T, Schürmann M. P300-response: possible psychophysiological correlates in delta and theta frequency channels. A review. Int J Psychophysiol. 1992;13(2):161–179. PubMed

Harmony T, Fernández T, Silva J, et al. EEG delta activity: an indicator of attention to internal processing during performance of mental tasks. Int J Psychophysiol. 1996;24(1–2):161–171. PubMed

Klimesch W, Schimke H, Schwaiger J. Episodic and semantic memory: an analysis in the EEG theta and alpha band. Electroencephalogr Clin Neurophysiol. 1994;91(6):428–441. PubMed

Rangaswamy M, Porjesz B, Chorlian DB, et al. Resting EEG in offspring of male alcoholics: beta frequencies. Int J Psychophysiol. 2004;51(3):239–251. PubMed

Maltby N, Tolin DF, Worhunsky P, O’Keefe TM, Kiehl KA. Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. Neuroimage. 2005;24(2):495–503. PubMed

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