CD49b defines functionally mature Treg cells that survey skin and vascular tissues
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
F30 AI122721
NIAID NIH HHS - United States
P30 CA008748
NCI NIH HHS - United States
R37 AI034206
NIAID NIH HHS - United States
T32 GM007739
NIGMS NIH HHS - United States
Howard Hughes Medical Institute - United States
PubMed
30355617
PubMed Central
PMC6219731
DOI
10.1084/jem.20181442
PII: jem.20181442
Knihovny.cz E-zdroje
- MeSH
- cévy imunologie MeSH
- imunitní dozor * MeSH
- integrin alfa2 genetika imunologie MeSH
- kůže krevní zásobení cytologie imunologie MeSH
- lymfatické uzliny krevní zásobení cytologie imunologie MeSH
- myši transgenní MeSH
- myši MeSH
- regulační T-lymfocyty cytologie imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- integrin alfa2 MeSH
Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α2 integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b+ Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.
Center of Life Sciences Skolkovo Institute of Science and Technology Moscow Russia
Central European Institute of Technology Masaryk University Brno Czech Republic
Department of Applied Physics and Applied Mathematics Columbia University New York NY
Privolzhsky Research Medical University Nizhny Novgorod Russia
Program for Computational and Systems Biology Memorial Sloan Kettering Cancer Center New York NY
Single Cell Research Initiative Memorial Sloan Kettering Cancer Center New York NY
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