Isothiocyanate from Broccoli, Sulforaphane, and Its Properties
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
30372361
DOI
10.1089/jmf.2018.0024
Knihovny.cz E-resources
- MeSH
- Autistic Disorder * drug therapy MeSH
- Brassica chemistry MeSH
- Antineoplastic Agents, Phytogenic therapeutic use MeSH
- Glucosinolates metabolism MeSH
- Imidoesters metabolism MeSH
- Isothiocyanates * chemistry pharmacology therapeutic use MeSH
- Humans MeSH
- Neoplasms * prevention & control MeSH
- Osteoporosis drug therapy MeSH
- Oximes MeSH
- Sulfoxides MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Antineoplastic Agents, Phytogenic MeSH
- glucoraphanin MeSH Browser
- Glucosinolates MeSH
- Imidoesters MeSH
- Isothiocyanates * MeSH
- Oximes MeSH
- sulforaphane MeSH Browser
- Sulfoxides MeSH
Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits. It has been shown that sulforaphane may protect against various types of cancer, may also decrease the risk of cardiovascular disease, and help in autism and osteoporosis. Our review offers a short summary of interesting properties of sulforaphane. Both the in vitro and in vivo methods/models and clinical studies are mentioned.
References provided by Crossref.org
