Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30419552
DOI
10.1016/j.eplepsyres.2018.11.001
PII: S0920-1211(18)30369-3
Knihovny.cz E-resources
- Keywords
- CGP46381, Immature rats, Pentylenetetrazol, Status epilepticus,
- MeSH
- GABA-B Receptor Antagonists therapeutic use MeSH
- Convulsants therapeutic use MeSH
- Rats MeSH
- Phosphinic Acids therapeutic use MeSH
- Disease Models, Animal MeSH
- Animals, Newborn MeSH
- Pentylenetetrazole toxicity MeSH
- Pilocarpine toxicity MeSH
- Rats, Wistar MeSH
- Status Epilepticus chemically induced drug therapy MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3-amino-2-hydroxypropylcyclohexylmethylphosphinic acid MeSH Browser
- GABA-B Receptor Antagonists MeSH
- Convulsants MeSH
- Phosphinic Acids MeSH
- Pentylenetetrazole MeSH
- Pilocarpine MeSH
Possible proconvulsant action of GABAB receptor antagonist CGP46381 was studied 3 and 13 days after status epilepticus elicited in 12-day-old rats. GABAA-dependent activity was tested by pentylenetetrazol administration and found different in 15-day-old rats after status epiolepticus but not in the older group. The interaction of the two GABAergic systems should be studied in detail.
References provided by Crossref.org
