Differences in serum steroid hormones concentrations in Spontaneously Hypertensive Rats (SHR) - an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD)
Language English Country Czech Republic Media print-electronic
Document type Journal Article
PubMed
30433797
DOI
10.33549/physiolres.933907
PII: 933907
Knihovny.cz E-resources
- MeSH
- Biomarkers blood MeSH
- Hydrocortisone blood MeSH
- Attention Deficit Disorder with Hyperactivity blood physiopathology MeSH
- Hypertension blood physiopathology MeSH
- Corticosterone blood MeSH
- Rats MeSH
- Disease Models, Animal * MeSH
- Gonadal Steroid Hormones blood MeSH
- Rats, Inbred SHR MeSH
- Rats, Inbred WKY MeSH
- Progesterone blood MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- Hydrocortisone MeSH
- Corticosterone MeSH
- Gonadal Steroid Hormones MeSH
- Progesterone MeSH
Spontaneously hypertensive rats are the most common animal model used to study attention deficit hyperactivity disorder (ADHD). The present study investigated the levels of steroid hormones in the bloodstream of hypertensive rats and its normotensive control strain, Wistar-Kyoto rats, to check if there are any hormonal differences between both strains at the onset of ADHD. Plasma samples were collected from young (5-week-old) and mature (10-week-old) male hypertensive and normotensive rats to determine the serum level of testosterone, 17beta-estradiol, free estriol, progesterone, corticosterone and cortisol using ELISA kits. The results showed statistically significant increases in serum levels of testosterone and free estriol in 10-week-old hypertensive and normotensive rats when compared to 5-week-old animals. Moreover, the concentrations of progesterone, corticosterone and cortisol were significantly elevated in 10-week-old hypertensive rats when compared to 5-week-old animals of both strains as well as 10-week-old normotensive rats. Hormonal differences observed between 10-week-old hypertensive and normotensive rats were also accompanied by differences in the volumes of lateral ventricles as well as the third ventricle and cerebral aqueduct. In conclusion, elevated contents of progesterone, corticosterone and cortisol in hypertensive rats may be associated not only with ADHD but also with developing hypertension. This question needs further study.
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