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Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study

Jensen, Poul Erik H
Autor Jensen, Poul Erik H Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: poul.erik.h.jensen@regionh.dk
Warnke, Clemens
Autor Warnke, Clemens Department of Neurology, University Hospital Köln, Köln, Germany; University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: clemens.warnke@uk-koeln.de
Ingenhoven, Kathleen
Autor Ingenhoven, Kathleen University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: Kathleen.Ingenhoven@med.uni-duesseldorf.de
Piccoli, Luca
Autor Piccoli, Luca Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland. Electronic address: luca.piccoli@irb.usi.ch
Gasis, Marcia
Autor Gasis, Marcia University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: gasis@hhu.de
Hermanrud, Christina
Autor Hermanrud, Christina Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: christina.hermanrud@ki.se
Fernandez-Rodriguez, Blanca M
Autor Fernandez-Rodriguez, Blanca M Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland. Electronic address: blanca.fernandez@irb.usi.ch
Ryner, Malin
Autor Ryner, Malin Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Kramer, Daniel
Autor Kramer, Daniel Sanofi-Aventis Germany, Frankfurt Am Main, Germany. Electronic address: daniel.kramer@sanofi.com
Link, Jenny
Autor Link, Jenny Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: jenny.link@ki.se
Ramanujam, Ryan
Autor Ramanujam, Ryan Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; KTH - Royal Institute of Technology, Stockholm, Sweden. Electronic address: Ryan.Ramanujam@ki.se
Auer, Michael
Autor Auer, Michael Innsbruck Medical University, Innsbruck, Austria. Electronic address: Michael.Auer@student.i-med.ac.at
Buck, Dorothea
Autor Buck, Dorothea Department of Neurology, Technische Universität München, Munich, Germany. Electronic address: dorothea.buck@tum.de
Grummel, Verena
Autor Grummel, Verena Department of Neurology, Technische Universität München, Munich, Germany. Electronic address: v.grummel@tum.de
Bertotti, Elisa
Autor Bertotti, Elisa Merck NBE Bioanalytics Ivrea, Colleretto Giacosa, Italy. Electronic address: elisa.bertotti@merckgroup.com
Fissolo, Nicolas
Autor Fissolo, Nicolas Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain. Electronic address: nicolas.fissolo@vhir.org
Oliver-Martos, Begoña
Autor Oliver-Martos, Begoña Hospital Regional Universitario de Málaga, Instituto de investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain
Nytrova, Petra
Autor Nytrova, Petra MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: Petra.Nytrova@lf1.cuni.cz
Khalil, Michael
Autor Khalil, Michael Department of Neurology, Medical University of Graz, Graz, Austria. Electronic address: michael.khalil@medunigraz.at
Guger, Michael
Autor Guger, Michael Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria. Electronic address: Michael.Guger@kepleruniklinikum.at
Rathmaier, Sandra
Autor Rathmaier, Sandra Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria. Electronic address: Sandra.Rathmaier@kepleruniklinikum.at
Sievers-Stober, Claudia
Autor Sievers-Stober, Claudia Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: claudia.sievers-stober@unibas.ch
Lindberg, Raija L P
Autor Lindberg, Raija L P Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: Raija.Lindberg@unibas.ch
Hässler, Signe
Autor Hässler, Signe CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France. Electronic address: signe.hassler@inserm.fr
Bachelet, Delphine
Autor Bachelet, Delphine CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France. Electronic address: delphine.bachelet@inserm.fr
Aktas, Orhan
Autor Aktas, Orhan University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: orhan.aktas@uni-duesseldorf.de
Donnellan, Naoimh
Autor Donnellan, Naoimh Ipsen Biopharm Ltd., Berkshire, United Kingdom
Lawton, Andy
Autor Lawton, Andy GlaxoSmithKline R&D, Uxbridge, Middlesex, United Kingdom. Electronic address: andy.m.lawton@gsk.com
Hemmer, Bernhard
Autor Hemmer, Bernhard Department of Neurology, Technische Universität München, Munich, Germany; Munich Cluster for systems Neurology (SyNergy), Munich, Germany. Electronic address: hemmer@lrz.tu-muenchen.de
Havrdova, Eva Kubala
Autor Havrdova, Eva Kubala MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: eva.havrdova@lf1.cuni.cz
Kieseier, Bernd
Autor Kieseier, Bernd University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: Bernd.Kieseier@uni-duesseldorf.de
Hartung, Hans-Peter
Autor Hartung, Hans-Peter University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: hans-peter.hartung@uni-duesseldorf.de
Comabella, Manuel
Autor Comabella, Manuel Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain. Electronic address: manuel.comabella@vhir.org
Montalban, Xavier
Autor Montalban, Xavier Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain. Electronic address: xavier.montalban@unic-em.com
Derfuss, Tobias
Autor Derfuss, Tobias Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: Tobias.Derfuss@usb.ch
Sellebjerg, Finn
Autor Sellebjerg, Finn Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: finn.thorup.sellebjerg@regionh.dk
Dönnes, Pierre
Autor Dönnes, Pierre SciCross AB, Skövde, Sweden. Electronic address: pierre@scicross.com
Pallardy, Marc
Autor Pallardy, Marc INSERM UMR 996, Univ. Paris-Sud, Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address: marc.pallardy@u-psud.fr
Spindeldreher, Sebastian
Autor Spindeldreher, Sebastian Drug Metabolism Pharmacokinetics-Biologics, Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: sebastian.spindeldreher@novartis.com
Broët, Philippe
Autor Broët, Philippe CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France; Assistance Publique - Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France. Electronic address: philippe.broet@inserm.fr
Deisenhammer, Florian
Autor Deisenhammer, Florian Innsbruck Medical University, Innsbruck, Austria. Electronic address: Florian.Deisenhammer@tirol-kliniken.at
Fogdell-Hahn, Anna
Autor Fogdell-Hahn, Anna Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: Anna.Fogdell-Hahn@ki.se
Sorensen, Per Soelberg
Autor Sorensen, Per Soelberg Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: Per.Soelberg.Soerensen@regionh.dk
ABIRISK Consortium
Autor ABIRISK Consortium

Journal of neuroimmunology. 2019 Jan 15 ; 326 () : 19-27. [epub] 20181107

J Neuroimmunol
ISSN 1872-8421 | 0165-5728
Zdroj

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid30447419

PubMed 30447419
DOI 10.1016/j.jneuroim.2018.11.002
PII: S0165-5728(18)30332-1
Knihovny.cz E-zdroje

Klíčová slova
Anti-drug antibodies, Bridging ELISA, Interferon-beta, Luciferase-based bioassay, Multiple sclerosis, Neutralizing antibodies,
MeSH
biotest MeSH
ELISA MeSH
imunologické faktory imunologie terapeutické užití MeSH
interferon beta imunologie terapeutické užití MeSH
lidé MeSH
neutralizační testy metody MeSH
neutralizující protilátky krev MeSH
roztroušená skleróza krev farmakoterapie MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
pozorovací studie MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH
Názvy látek
imunologické faktory MeSH
interferon beta MeSH
neutralizující protilátky MeSH

Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.

CESP INSERM UMR 1018 Faculty of Medicine Paris Sud University Paris Saclay University UVSQ Villejuif France

CESP INSERM UMR 1018 Faculty of Medicine Paris Sud University Paris Saclay University UVSQ Villejuif France; Assistance Publique Hôpitaux de Paris Hôpital Paul Brousse Villejuif France

Clinic for Neurology 2 Kepler University Clinic Med Campus 3 Linz Austria

Danish Multiple Sclerosis Center Department of Neurology Rigshospitalet University of Copenhagen Copenhagen Denmark

Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden; KTH Royal Institute of Technology Stockholm Sweden

Department of Neurology Medical University of Graz Graz Austria

Department of Neurology Technische Universität München Munich Germany

Department of Neurology Technische Universität München Munich Germany; Munich Cluster for systems Neurology Munich Germany

Department of Neurology University Hospital Köln Köln Germany; University of Düsseldorf Medical Faculty Department of Neurology Düsseldorf Germany

Departments of Biomedicine and Neurology University Hospital Basel and University of Basel Basel Switzerland

Drug Metabolism Pharmacokinetics Biologics Novartis Institutes for Biomedical Research Basel Switzerland