Fluorine-containing block/branched polyamphiphiles forming bioinspired complexes with biopolymers
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30476793
DOI
10.1016/j.colsurfb.2018.11.047
PII: S0927-7765(18)30828-2
Knihovny.cz E-zdroje
- Klíčová slova
- Antibacterial activity, Block/branched polyamphiphiles, Colloidal-chemical study, DLS, Gene delivery, Mass-spectrometry, Polyamphiphile/biopolymer complexes, TEM,
- MeSH
- DNA chemie metabolismus MeSH
- fluor chemie MeSH
- hydrofobní a hydrofilní interakce MeSH
- methakryláty chemie MeSH
- micely MeSH
- muramidasa chemie metabolismus MeSH
- plazmidy chemie metabolismus MeSH
- polyethylenglykoly chemie MeSH
- polymery chemie metabolismus MeSH
- technika přenosu genů MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 2-(dimethylamino)ethyl methacrylate MeSH Prohlížeč
- DNA MeSH
- fluor MeSH
- hen egg lysozyme MeSH Prohlížeč
- methakryláty MeSH
- micely MeSH
- muramidasa MeSH
- polyethylenglykoly MeSH
- polymery MeSH
Colloidal-chemical characteristics of block/branched cationic and non-ionic polyamphiphiles containing poly(fluorine-alkyl methacrylate) (poly(FMA)) block and their intermolecular complexes with biopolymers were studied. The dependences of their surface activity and micelle size on the length of hydrophobic and hydrophilic blocks, as well as the length of side fluorine-alkyl branches were established. Poly(FMA)-block-poly(DMAEMA) was used for formation of interpolyelectrolyte complexes with plasmid DNA (pDNA) via their electrostatic interaction. Novel non-viral polyplexes were tested as gene delivery systems for mammalian cells. The results of DLS, TEM and MALDI-ToF studies demonstrated disaggregation of lysozyme (LYZ) aggregates in the presence of poly(FMA)-block-poly(NVP) and formation of the polyamphiphile…LYS complex possessing antibacterial action.
Chuiko Institute of Surface Chemistry NAS of Ukraine Naumova str 17 03164 Kyiv Ukraine
Institute of Cell Biology NAS of Ukraine Drahomanova str 14 16 79005 Lviv Ukraine
Institute of Organic Chemistry NAS of Ukraine Murmanska str 5 02660 Kyiv Ukraine
Lviv Polytechnic National University S Bandery str 12 79013 Lviv Ukraine
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