The approach to the measurement of one-bond indirect spin-spin coupling constants between equivalent nuclei was revisited. The analytical formulas for development of the density matrix of strongly coupled symmetrical HC-C'H' spin systems were derived and the optimal duration of polarization delay in the original 2QHMBC pulse sequence is discussed. Based on the analytical formulas a new version of a robust indirect detection experiment, called SYMONA (SYmmetrical MOlecules Natural Abundance double-quantum experiment), was proposed for carbon-carbon coupling constants detection in symmetrical molecules. Additionally, application of the SYMONA experiment to more complicated spin systems than isolated HC-C'H' is discussed.

Institute of Chemical Process Fundamentals of the CAS v v i Rozvojova 135 165 02 Prague 6 Czech Republic

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