Oxidative stress: Normal pregnancy versus preeclampsia
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
30590104
DOI
10.1016/j.bbadis.2018.12.005
PII: S0925-4439(18)30491-5
Knihovny.cz E-resources
- Keywords
- Oxidative stress, Preeclampsia, RNS, ROS,
- MeSH
- Antioxidants therapeutic use MeSH
- Endothelial Cells metabolism MeSH
- Ischemia metabolism MeSH
- Humans MeSH
- Melatonin metabolism MeSH
- Oxidation-Reduction MeSH
- Oxidative Stress physiology MeSH
- Placenta metabolism MeSH
- Pre-Eclampsia drug therapy metabolism MeSH
- Reactive Nitrogen Species metabolism MeSH
- Reactive Oxygen Species metabolism MeSH
- Signal Transduction MeSH
- Pregnancy metabolism MeSH
- Free Radicals MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Pregnancy metabolism MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antioxidants MeSH
- Melatonin MeSH
- Reactive Nitrogen Species MeSH
- Reactive Oxygen Species MeSH
- Free Radicals MeSH
The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS play an important role as secondary messengers in many intracellular signalling cascades. However, they can also exert critical effects on pathological processes involving the pregnant woman. ROS, RNS and antioxidants establish a balance that determines the oxidation status of animals and humans. This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia.
Center for Biophysics and Biochemistry AP 21827 Caracas 1020A Venezuela
Departamento de Fisiología Facultad de Farmacia Universidad de Sevilla Seville Spain
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