Effect of pallidal deep-brain stimulation on articulation rate in dystonia
Language English Country Italy Media print-electronic
Document type Journal Article
Grant support
16-13323S
Grantová Agentura České Republiky
16-19975S
Grantová Agentura České Republiky
15-28038A
Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/0.0/16_019/0000765
Research Center for Informatics
PROGRES-Q27/LF1
Ministerstvo Školství, Mládeže a Tělovýchovy
PubMed
30623266
DOI
10.1007/s10072-019-3702-5
PII: 10.1007/s10072-019-3702-5
Knihovny.cz E-resources
- Keywords
- Acoustic analysis, Deep-brain stimulation, Dysarthria, Dystonia, Pallidal, Speech,
- MeSH
- Adult MeSH
- Dysarthria etiology MeSH
- Dystonic Disorders therapy MeSH
- Globus Pallidus * MeSH
- Deep Brain Stimulation adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia.
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