Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, pozorovací studie
PubMed
30628026
DOI
10.1007/s10792-018-01063-8
PII: 10.1007/s10792-018-01063-8
Knihovny.cz E-zdroje
- Klíčová slova
- Diabetic retinopathy, Ellipsoid zone, Glycated hemoglobin, Serum calcium, Spectral-domain optical coherence tomography,
- MeSH
- analýza rozptylu MeSH
- diabetická retinopatie patofyziologie MeSH
- dospělí MeSH
- fotoreceptory obratlovců patologie MeSH
- glykovaný hemoglobin analýza MeSH
- hyperglykemie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- průřezové studie MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- vápník krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Názvy látek
- glykovaný hemoglobin MeSH
- vápník MeSH
PURPOSE: To study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). METHODS: This is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c < 7, n = 26) and group 2 (HbA1c > 7, n = 37). Data were analyzed statistically. RESULTS: Mean ionic calcium levels in group 1 and group 2 were 1.131 ± 0.073 mmol/dL and 1.170 ± 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p = 0.01) in group 2 cases. CONCLUSION: Increased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c > 7 in DR.
Department of Biochemistry King George's Medical University Lucknow India
Department of Internal Medicine Brothers of Mercy Hospital Polni 3 639 00 Brno Czech Republic
Department of Pharmacology Lady Hardinge Medical College New Delhi India
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