Mediterranean diet, cardiovascular disease and mortality in diabetes: A systematic review and meta-analysis of prospective cohort studies and randomized clinical trials
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, metaanalýza, systematický přehled
- Klíčová slova
- Mediterranean diet, cardiovascular disease, cardiovascular mortality, diabetes, meta-analysis,
- MeSH
- diabetes mellitus epidemiologie MeSH
- kardiovaskulární nemoci mortalita prevence a kontrola MeSH
- kohortové studie MeSH
- lidé MeSH
- randomizované kontrolované studie jako téma MeSH
- strava středomořská statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- systematický přehled MeSH
To update the clinical practice guidelines for nutrition therapy of the European Association for the Study of Diabetes, we conducted a systematic review and meta-analysis of prospective cohort studies and randomized clinical trials (RCTs) to evaluate the effect of the Mediterranean diet (MedDiet) on the prevention of cardiovascular disease (CVD) incidence and mortality. We searched Medline, EMBASE (through April 20, 2018) and Cochrane (through May 7, 2018) databases. Pooled relative risks (RRs) and 95% confidence interval (CI) were calculated by the generic inverse variance method. A total of 41 reports (3 RCTs and 38 cohorts) were included. Meta-analyses of RCTs revealed a beneficial effect of the MedDiet on total CVD incidence (RR: 0.62; 95% CI: 0.50, 0.78) and total myocardial infarction (MI) incidence (RR: 0.65; 95% CI: 0.49, 0.88). Meta-analyses of prospective cohort studies, which compared the highest versus lowest categories of MedDiet adherence, revealed an inverse association with total CVD mortality (RR: 0.79; 95% CI: 0.77, 0.82), coronary heart disease (CHD) incidence (RR: 0.73; 95% CI: 0.62, 0.86), CHD mortality (RR: 0.83; 95% CI: 0.75, 0.92), stroke incidence (RR: 0.80; 95% CI: 0.71, 0.90), stroke mortality (RR: 0.87; 95% CI: 0.80, 0.96) and MI incidence (RR: 0.73; 95% CI: 0.61, 0.88). The present study suggests that MedDiet has a beneficial role on CVD prevention in populations inclusive of individuals with diabetes.
College of Pharmacy and Nutrition University of Saskatchewan Saskatoon Saskatchewan Canada
Department of Nutritional Sciences Faculty of Medicine University of Toronto Toronto Ontario Canada
Institut d'Investigació Sanitària Pere Virgili Reus Spain
Institute for Clinical and Experimental Medicine Prague Czech Republic
Li Ka Shing Knowledge Institute St Michael's Hospital Toronto Ontario Canada
Nutrition Unit University Hospital of Sant Joan de Reus Reus Spain
Physicians Committee for Responsible Medicine Washington DC USA
School of Medicine University of Zagreb Zagreb Croatia
Unitat de Nutrició Departament de Bioquímica i Biotecnologia Universitat Rovira i Virgili Reus Spain
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