Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase
Jazyk angličtina Země Spojené arabské emiráty Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
30706778
DOI
10.2174/0929867326666190130161202
PII: CMC-EPUB-96228
Knihovny.cz E-zdroje
- Klíčová slova
- Acetylcholinesterase, anesthesia, butyrylcholinesterase, diagnosis, liver function test, myorelaxant, nerve agent, neurotransmission, pesticide, poisoning.,
- MeSH
- acetylcholinesterasa metabolismus MeSH
- Alzheimerova nemoc MeSH
- butyrylcholinesterasa metabolismus MeSH
- cholinesterasové inhibitory MeSH
- lidé MeSH
- pesticidy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- butyrylcholinesterasa MeSH
- cholinesterasové inhibitory MeSH
- pesticidy MeSH
Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer´s disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.
Citace poskytuje Crossref.org
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