Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
30769281
DOI
10.1016/j.etap.2019.02.002
PII: S1382-6689(18)30306-5
Knihovny.cz E-resources
- Keywords
- Antioxidant enzymes, TBARS, ctsk, opa1, pklr,
- MeSH
- Anti-Bacterial Agents toxicity MeSH
- Water Pollutants, Chemical toxicity MeSH
- Zebrafish MeSH
- Enrofloxacin toxicity MeSH
- Adaptation, Physiological MeSH
- Liver drug effects metabolism MeSH
- Oxidative Stress drug effects MeSH
- Gene Expression Regulation drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Water Pollutants, Chemical MeSH
- Enrofloxacin MeSH
The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 μg/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Moreover, lipid peroxidation was observed at the highest concentration. No significant changes either in catalytic activity of antioxidant enzymes or elevated lipid peroxidation were observed from sampling day 7 on. mRNA expression of genes encoding antioxidant enzymes was also not affected by enrofloxacin after a 14-day exposure. This suggests the ability of D. rerio juveniles to adapt to enrofloxacin in a short time period. Moreover, enrofloxacin was not shown to affect collagen, cathepsin K, optic atrophy 1 and pyruvate kinase L/R mRNA expression in this study.
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