Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30769281
DOI
10.1016/j.etap.2019.02.002
PII: S1382-6689(18)30306-5
Knihovny.cz E-zdroje
- Klíčová slova
- Antioxidant enzymes, TBARS, ctsk, opa1, pklr,
- MeSH
- antibakteriální látky toxicita MeSH
- chemické látky znečišťující vodu toxicita MeSH
- dánio pruhované MeSH
- enrofloxacin toxicita MeSH
- fyziologická adaptace MeSH
- játra účinky léků metabolismus MeSH
- oxidační stres účinky léků MeSH
- regulace genové exprese účinky léků MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- chemické látky znečišťující vodu MeSH
- enrofloxacin MeSH
The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 μg/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Moreover, lipid peroxidation was observed at the highest concentration. No significant changes either in catalytic activity of antioxidant enzymes or elevated lipid peroxidation were observed from sampling day 7 on. mRNA expression of genes encoding antioxidant enzymes was also not affected by enrofloxacin after a 14-day exposure. This suggests the ability of D. rerio juveniles to adapt to enrofloxacin in a short time period. Moreover, enrofloxacin was not shown to affect collagen, cathepsin K, optic atrophy 1 and pyruvate kinase L/R mRNA expression in this study.
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