The effect of the antidepressant venlafaxine on gene expression of biotransformation enzymes in zebrafish (Danio rerio) embryos
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
202/2017/FVHE
Veterinární a Farmaceutická Univerzita Brno
LO1218
Ministerstvo Školství, Mládeže a Tělovýchovy
CZ.02.1.01/0.0/0.0/16_019/0000869
ERDF/ESF
PubMed
31755053
DOI
10.1007/s11356-019-06726-2
PII: 10.1007/s11356-019-06726-2
Knihovny.cz E-zdroje
- Klíčová slova
- : ABC transporters, Metabolism, Pharmaceutical, Regulation, Xenobiotics, Zebrafish, pxr,
- MeSH
- antidepresiva farmakologie MeSH
- biotransformace MeSH
- chemické látky znečišťující vodu farmakologie MeSH
- dánio pruhované * MeSH
- embryo nesavčí účinky léků enzymologie MeSH
- regulace genové exprese enzymů * MeSH
- venlafaxin hydrochlorid farmakologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antidepresiva MeSH
- chemické látky znečišťující vodu MeSH
- venlafaxin hydrochlorid MeSH
The effect of venlafaxine, a pharmaceutical commonly found in aquatic environment, was analyzed on non-target organism, Danio rerio (Hamilton, 1822). D. rerio embryos were treated by two different concentrations of venlafaxine: either concentration relevant in aquatic environment (0.3 μg/L) or concentration that was two orders of magnitude higher (30 μg/L) for the evaluation of dose-dependent effect. Time-dependent effect was rated at 24, 96, and 144 h post-fertilization (hpf). For gene expression, genes representing one of the phases of xenobiotic biotransformation (0 to III) were selected. The results of this study showed that the effect of venlafaxine on the zebrafish embryos is the most evident at hatching (96 hpf). At this time, the results showed a downregulation of gene expression in each phase of biotransformation and in both tested concentrations. In contrast, an upregulation of most of the genes was observed 144 hpf for both tested venlafaxine concentrations. The study shows that venlafaxine can affect the gene expression of biotransformation enzymes in D. rerio embryos even in the environmentally relevant concentration and thus disrupt the process of biotransformation. Moreover, the pxr regulation of genes seems to be disrupted after venlafaxine exposure in dose- and time-dependent manner.
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Aquat Toxicol. 2019 Sep;214:105258 PubMed
Front Physiol. 2014 Jul 22;5:266 PubMed
Endocr Rev. 2002 Oct;23(5):687-702 PubMed
Clin Ther. 2008 Jul;30(7):1206-27 PubMed
Environ Sci Pollut Res Int. 2018 Mar;25(9):8542-8549 PubMed
Environ Sci Technol. 2008 Jun 1;42(11):3914-20 PubMed
Aquat Toxicol. 2010 Oct 1;100(1):91-100 PubMed
Indian J Pharmacol. 2012 Jan;44(1):20-5 PubMed
Sci Total Environ. 2018 Sep 15;636:220-229 PubMed
Hum Psychopharmacol. 2004 Jan;19(1):9-16 PubMed
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):172-9 PubMed
Toxicol Sci. 2007 Nov;100(1):168-79 PubMed
J Hazard Mater. 2010 Mar 15;175(1-3):45-95 PubMed
Environ Toxicol Pharmacol. 2019 Apr;67:87-93 PubMed
Microsc Res Tech. 2019 Jul;82(7):1224-1230 PubMed
BMC Biol. 2013 Jun 17;11:69 PubMed
Environ Sci Pollut Res Int. 2016 Jun;23(11):10615-10629 PubMed
Comp Biochem Physiol C Toxicol Pharmacol. 2018 Oct;212:34-46 PubMed
Mol Reprod Dev. 2019 Oct;86(10):1348-1356 PubMed
Comp Biochem Physiol C Toxicol Pharmacol. 2017 Oct;200:34-41 PubMed
Int J Mol Sci. 2018 Dec 10;19(12):null PubMed
Toxicol Sci. 2015 Feb;143(2):398-407 PubMed
Chemosphere. 2019 Feb;217:516-521 PubMed
Chemosphere. 2017 Dec;188:414-423 PubMed
Environ Toxicol Pharmacol. 2019 May;68:61-74 PubMed
Annu Rev Genomics Hum Genet. 2005;6:123-42 PubMed
Aquat Toxicol. 2013 May 15;132-133:200-11 PubMed
Dev Dyn. 1995 Jul;203(3):253-310 PubMed
Ecotoxicol Environ Saf. 2006 Mar;63(3):378-88 PubMed
Aquat Toxicol. 2011 Jul;104(1-2):38-47 PubMed
Environ Sci Technol. 2017 Nov 7;51(21):12889-12897 PubMed
Sci Total Environ. 2013 Jun 1;454-455:442-56 PubMed
Environ Toxicol Pharmacol. 2003 Feb;13(2):57-149 PubMed
Sci Total Environ. 2018 Aug 1;631-632:789-794 PubMed
BMC Genomics. 2010 Nov 18;11:643 PubMed
Nitric Oxide. 2008 Aug;19(1):36-41 PubMed
Toxins (Basel). 2019 May 08;11(5): PubMed
J Toxicol Sci. 2016 Feb;41(1):1-11 PubMed
Aquat Toxicol. 2013 Oct 15;142-143:447-57 PubMed
Chemosphere. 2019 Jun;224:616-625 PubMed
Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):109-20 PubMed
Environ Toxicol. 2016 Feb;31(2):201-10 PubMed
Sci Total Environ. 2019 Feb 25;653:1120-1127 PubMed
Aquat Toxicol. 2000 Apr 1;48(4):357-389 PubMed
Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr;140(3-4):403-7 PubMed
Environ Toxicol Pharmacol. 2015 Sep;40(2):343-8 PubMed
Sci Total Environ. 2018 Dec 15;645:79-88 PubMed
Environ Toxicol Chem. 2009 Dec;28(12):2677-84 PubMed
Arch Pharm Res. 2005 Mar;28(3):249-68 PubMed
J Affect Disord. 1998 Dec;51(3):237-54 PubMed
Microsc Res Tech. 2018 Jul;81(7):724-729 PubMed
Aquat Toxicol. 2014 Mar;148:130-8 PubMed
Neuro Endocrinol Lett. 2013;34 Suppl 2:102-8 PubMed
Environ Sci Pollut Res Int. 2008 Jul;15(5):394-404 PubMed
Chemosphere. 2014 Nov;115:31-9 PubMed
BMC Evol Biol. 2008 Apr 02;8:103 PubMed
Aquat Toxicol. 2013 Jan 15;126:30-41 PubMed
Sci Total Environ. 2018 May 1;622-623:214-221 PubMed
J Clin Pharmacol. 1992 Aug;32(8):716-24 PubMed
Sci Total Environ. 2014 Aug 1;488-489:46-50 PubMed
Sci Total Environ. 2019 May 15;665:718-723 PubMed
Comp Biochem Physiol C Toxicol Pharmacol. 2010 Mar;151(2):209-15 PubMed
Ecotoxicol Environ Saf. 2018 Oct 30;162:147-159 PubMed
Sci Rep. 2017 Dec 5;7(1):17001 PubMed
Aquat Toxicol. 2017 Jan;182:20-30 PubMed
