- MeSH
- amisulprid aplikace a dávkování farmakologie terapeutické užití MeSH
- antidepresiva * škodlivé účinky MeSH
- antipsychotika škodlivé účinky MeSH
- bolesti zad komplikace MeSH
- depresivní poruchy farmakoterapie komplikace MeSH
- krvácení chemicky indukované prevence a kontrola MeSH
- lidé středního věku MeSH
- lidé MeSH
- lithium * farmakokinetika farmakologie terapeutické užití MeSH
- nenasazení léčby MeSH
- perioperační péče metody MeSH
- poruchy osobnosti farmakoterapie komplikace MeSH
- pregabalin terapeutické užití MeSH
- venlafaxin hydrochlorid farmakologie terapeutické užití MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
The effect of venlafaxine, a pharmaceutical commonly found in aquatic environment, was analyzed on non-target organism, Danio rerio (Hamilton, 1822). D. rerio embryos were treated by two different concentrations of venlafaxine: either concentration relevant in aquatic environment (0.3 μg/L) or concentration that was two orders of magnitude higher (30 μg/L) for the evaluation of dose-dependent effect. Time-dependent effect was rated at 24, 96, and 144 h post-fertilization (hpf). For gene expression, genes representing one of the phases of xenobiotic biotransformation (0 to III) were selected. The results of this study showed that the effect of venlafaxine on the zebrafish embryos is the most evident at hatching (96 hpf). At this time, the results showed a downregulation of gene expression in each phase of biotransformation and in both tested concentrations. In contrast, an upregulation of most of the genes was observed 144 hpf for both tested venlafaxine concentrations. The study shows that venlafaxine can affect the gene expression of biotransformation enzymes in D. rerio embryos even in the environmentally relevant concentration and thus disrupt the process of biotransformation. Moreover, the pxr regulation of genes seems to be disrupted after venlafaxine exposure in dose- and time-dependent manner.
- MeSH
- antidepresiva farmakologie MeSH
- biotransformace MeSH
- chemické látky znečišťující vodu farmakologie MeSH
- dánio pruhované * MeSH
- embryo nesavčí účinky léků enzymologie MeSH
- regulace genové exprese enzymů * MeSH
- venlafaxin hydrochlorid farmakologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
