Diastolic dysfunction in asymptomatic hemodialysis patients in the light of the current echocardiographic guidelines
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30815807
DOI
10.1007/s10554-019-01564-2
PII: 10.1007/s10554-019-01564-2
Knihovny.cz E-zdroje
- Klíčová slova
- Chronic kidney disease, Diastolic dysfunction, Echocardiography, Heart failure, Hemodialysis,
- MeSH
- asymptomatické nemoci MeSH
- biologické markery krev MeSH
- časové faktory MeSH
- chronické selhání ledvin komplikace diagnóza patofyziologie terapie MeSH
- dialýza ledvin * škodlivé účinky MeSH
- diastola MeSH
- dopplerovská echokardiografie * MeSH
- dysfunkce levé srdeční komory diagnostické zobrazování etiologie patofyziologie MeSH
- funkce levé komory srdeční * MeSH
- hypertrofie levé komory srdeční diagnostické zobrazování etiologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- natriuretický peptid typu B krev MeSH
- prediktivní hodnota testů MeSH
- remodelace komor MeSH
- rizikové faktory MeSH
- senioři MeSH
- tepový objem MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- natriuretický peptid typu B MeSH
The prevalence of the left ventricular hypertrophy (LVH) is very high in end-stage renal disease treated by hemodialysis. Diastolic dysfunction is a frequent consequence and leads to the development of heart failure with preserved ejection fraction. New American/European echocardiographic guidelines for the assessment of diastolic function simplified the evaluation and were published recently. The aim of this study was to reveal if the new guidelines stratify asymptomatic hemodialysis patients by the levels of brain-natriuretic peptide (BNP). A cohort of 46 patients hemodialyzed in one center with the lack of overt heart failure, systolic dysfunction, arrhythmia or significant valvular disease were examined by echocardiography before and after a single hemodialysis and blood samples for BNP analysis were drawn at both occasions. The LVH was present in 53% of patients, concentric remodeling in another 17%. Higher indexed left ventricular mass was related to higher BNP levels (r = 0.58, p = 0.0001). Before hemodialysis, diastolic dysfunction was present in 61%: grade 1 in 25%, grade 2 in 21% and grade 3 in 8%. The higher grade of diastolic dysfunction was associated with the incremental increase of BNP. The post-dialysis echocardiography did not allow the assessment of diastolic function in as many as 37% of patients. Our study has shown that the application of the current guidelines for the assessment of diastolic function based on simple four criteria differentiate hemodialysis symptomless patients with preserved systolic function according to BNP levels. BNP levels also rose together with the left ventricular mass. The ratio E/e' medial seemed to be a better predictor of increased BNP than E/e' lateral or E/e' averaged.
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