Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
2017 FI_B 00617, 2018 FI_B1 00174 and 2019 FI_B2 00167
Departament d'Universitats, Recerca i Societat de la Informació - International
2017 DI 072
Departament d'Universitats, Recerca i Societat de la Informació - International
CTQ2015-64319-R
Ministerio de Economía, Industria y Competitividad, Gobierno de España - International
CTQ2017-84779-R
Ministerio de Economía, Industria y Competitividad, Gobierno de España - International
CTQ2014-52658-R
Ministerio de Economía, Industria y Competitividad, Gobierno de España - International
CTQ2016-78454-C2-1-R
Ministerio de Economía, Industria y Competitividad, Gobierno de España - International
18-09502S
Czech Science Foundation - International
R-1034/2016
Universidad de Murcia - International
CTQ2015-64319-R
FEDER funds - International
CTQ2017-84779-R
FEDER funds - International
CTQ2014-52658-R
FEDER funds - International
CTQ2016-78454-C2-1-R
FEDER funds - International
PubMed
30889300
DOI
10.1002/anie.201901268
Knihovny.cz E-zdroje
- Klíčová slova
- conjugation, coumarin, cyclometalated iridium(III) complexes, photodynamic therapy, photosensitizer,
- MeSH
- fotochemoterapie MeSH
- HeLa buňky MeSH
- hypoxie buňky MeSH
- iridium chemie MeSH
- komplexní sloučeniny chemie farmakologie terapeutické užití MeSH
- kumariny chemie MeSH
- lidé MeSH
- nádory farmakoterapie patologie MeSH
- protinádorové látky chemie farmakologie terapeutické užití MeSH
- superoxidy metabolismus MeSH
- světlo MeSH
- viabilita buněk účinky léků účinky záření MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- coumarin MeSH Prohlížeč
- iridium MeSH
- komplexní sloučeniny MeSH
- kumariny MeSH
- protinádorové látky MeSH
- superoxidy MeSH
Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated IrIII complex conjugated to a far-red-emitting coumarin, IrIII -COUPY, is reported with highly favourable properties for cancer phototherapy. IrIII -COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Citace poskytuje Crossref.org
