JNK signaling in cancer cell survival
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
30912203
DOI
10.1002/med.21574
Knihovny.cz E-zdroje
- Klíčová slova
- JNK, c-Jun N-terminal kinase, cancer, cell survival, chemoresistance, tumor development,
- MeSH
- autofagie MeSH
- chemorezistence MeSH
- JNK mitogenem aktivované proteinkinasy metabolismus MeSH
- lidé MeSH
- MAP kinasový signální systém * MeSH
- nádory enzymologie patologie MeSH
- viabilita buněk MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- JNK mitogenem aktivované proteinkinasy MeSH
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor-β, toll-like receptors, interferon-γ, and autophagy, as well as compensatory JNK-dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK-mediated cancer cell survival. There is a focus on the specific "Yin and Yang" functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.
College of Life Science Yangtze University Jingzhou China
College of Veterinary Medicine Nanjing Agricultural University Nanjing China
Department of Microbiology and Immunobiology Harvard Medical School Boston MA
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