Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides
Jazyk angličtina Země Japonsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články
PubMed
30918138
PubMed Central
PMC6885603
DOI
10.2486/indhealth.2018-0146
Knihovny.cz E-zdroje
- Klíčová slova
- Follow-up, Metal nanoparticles, Telomere length,
- MeSH
- dospělí MeSH
- kovové nanočástice škodlivé účinky MeSH
- látky znečišťující vzduch v pracovním prostředí škodlivé účinky MeSH
- leukocyty MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidy MeSH
- pracovní expozice škodlivé účinky MeSH
- výzkumní pracovníci * MeSH
- zkracování telomer účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- látky znečišťující vzduch v pracovním prostředí MeSH
- oxidy MeSH
The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=-0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.
Center for Experimental Medicine Institute for Clinical and Experimental Medicine Czech Republic
Institute of Analytical Chemistry of the CAS Czech Republic
Institute of Chemical Process Fundamentals CAS Czech Republic
Zobrazit více v PubMed
Khanna P, Ong C, Bay BH, Baeg GH. (2015) Nanotoxicity: an interplay of oxidative stress, inflammation and cell death. Nanomaterials (Basel) 5, 1163–80. PubMed PMC
Pelclova D, Zdimal V, Kacer P, Fenclova Z, Vlckova S, Syslova K, Navratil T, Schwarz J, Zikova N, Barosova H, Turci F, Komarc M, Pelcl T, Belacek J, Kukutschova J, Zakharov S. (2016) Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production. J Breath Res 10, 016004. PubMed
Pelclova D, Zdimal V, Fenclova Z, Vlckova S, Turci F, Corazzari I, Kacer P, Schwarz J, Zikova N, Makes O, Syslova K, Komarc M, Belacek J, Navratil T, Machajova M, Zakharov S. (2016) Markers of oxidative damage of nucleic acids and proteins among workers exposed to TiO2 (nano) particles. Occup Environ Med 73, 110–8. PubMed
Pelclova D, Zdimal V, Kacer P, Zikova N, Komarc M, Fenclova Z, Vlckova S, Schwarz J, Makeš O, Syslova K, Navratil T, Turci F, Corazzari I, Zakharov S, Bello D. (2017) Markers of lipid oxidative damage in the exhaled breath condensate of nano TiO2 production workers. Nanotoxicology 11, 52–63. PubMed
Blackburn EH, Epel ES, Lin J. (2015) Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science 350, 1193–8. PubMed
Müezzinler A, Zaineddin AK, Brenner H. (2013) A systematic review of leukocyte telomere length and age in adults. Ageing Res Rev 12, 509–19. PubMed
Dlouha D, Pitha J, Lanska V, Hubacek JA. (2012) Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study. Clin Chim Acta 413, 1222–5. PubMed
Dlouha D, Maluskova J, Kralova Lesna I, Lanska V, Hubacek JA. (2014) Comparison of the relative telomere length measured in leukocytes and eleven different human tissues. Physiol Res 63 Suppl 3, S343–50. PubMed
Dlouhá D, Vančura V, Vymětalová J, Hubáček JA, Lánská V, Málek I. (2016) Can leukocyte telomere length predict survival time in heart transplant recipients over a minimal follow-up of 20 years? Folia Biol (Praha) 62, 188–93. PubMed
Zhang X, Lin S, Funk WE, Hou L. (2013) Environmental and occupational exposure to chemicals and telomere length in human studies. Occup Environ Med 70, 743–9. PubMed
Sohaebuddin SK, Thevenot PT, Baker D, Eaton JW, Tang L. (2010) Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol 7, 22. PubMed PMC
Glass DC, Mazhar M, Xiang S, Dean P, Simpson P, Priestly B, Plebanski M, Abramson M, Sim MR, Dennekamp M. (2017) Immunological effects among workers who handle engineered nanoparticles. Occup Environ Med 74, 868–76. PubMed
DNA Methylation Profiles in a Group of Workers Occupationally Exposed to Nanoparticles
