Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
30931891
DOI
10.14712/18059694.2019.40
PII: am_2019062010012
Knihovny.cz E-zdroje
- Klíčová slova
- disulfide, fibromyalgia, oxidative stress, thiol, thiol/disulfide homeostasis,
- MeSH
- antioxidancia metabolismus MeSH
- biologické markery krev MeSH
- disulfidy krev MeSH
- dospělí MeSH
- fibromyalgie krev patofyziologie MeSH
- homeostáza * MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidační stres fyziologie MeSH
- průřezové studie MeSH
- sulfhydrylové sloučeniny krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antioxidancia MeSH
- biologické markery MeSH
- disulfidy MeSH
- sulfhydrylové sloučeniny MeSH
BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.
Department of Biochemistry Istanbul Laboratory Istanbul Turkey
Department of Biochemistry Malatya Education and Research Hospital Malatya Turkey
Department of Clinical Biochemistry Ankara Education and Research Hospital Ankara Turkey
Department of Clinical Biochemistry Faculty of Medicine Yildirim Beyazit University Ankara Turkey
Department of Internal Medicine Camlica Erdem Hastanesi Istanbul Turkey
Departments of Orthopedics and Traumatology Antalya Training and Research Hospital Antalya Turkey
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