• MeSH
• Fibromyalgia * diagnosis   psychology   therapy   MeSH
• Humans MeSH
• Mind-Body Therapies MeSH
• Somatoform Disorders psychology   therapy   MeSH
• Fatigue Syndrome, Chronic * diagnosis   psychology   therapy   MeSH
• Irritable Bowel Syndrome * diagnosis   psychology   therapy   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

BACKGROUND: Fibromyalgia is a debilitating condition marked by persistent pain and reduced functionality. Various therapeutic methods have been suggested to alleviate symptoms in individuals with fibromyalgia, yet the impact of diverse rehabilitation strategies remains unclear. OBJECTIVE: This systematic review and meta-analysis aimed at assessing the efficacy of rehabilitation interventions in improving functioning in fibromyalgia patients. METHODS: We conducted a comprehensive literature search of multiple international databases (PubMed, Scopus, and Web of Science) from their inception until November 22nd, 2023. We identified 23 randomized controlled trials (RCTs) assessing multiple rehabilitation strategies. The primary outcome was the Fibromyalgia Impact Questionnaire (FIQ). Study quality was assessed using the Cochrane Risk-of-Bias Tool for Randomized Trials (RoB 2). The study protocol was registered in PROSPERO (CRD42020197666). RESULTS: Our meta-analysis rehabilitation interventions significantly reduce FIQ scores (MD =-11.74, 95% CI: -16.88 to -6.59, p< 0.0001). Notably, the subgroup analysis showed that different rehabilitation modalities seem to induce different therapeutic responses. CONCLUSIONS: Rehabilitation strategies hold promise in addressing the functional impairments and improving the overall well-being of individuals with fibromyalgia. The study underscores the need for further research to determine the optimal rehabilitation approach and its potential impact on the multilevel disability characterizing patients with fibromyalgia.

• MeSH
• Fibromyalgia * rehabilitation   MeSH
• Humans MeSH
• Randomized Controlled Trials as Topic MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Meta-Analysis MeSH
• Review MeSH
• Systematic Review MeSH

V článku autor referuje o novinkách u fibromyalgie jak z hlediska patofyziologie a diagnostiky, tak z hlediska hodnocení klinické manifestace i léčby. Za největší změnu lze pokládat současnou interpretaci patofyziologických mechanismů v mozku (nociplastická bolest), které jsou příčinou klinické manifestace příznaků, zejména rozsáhlých bolestí svalů a vazů. V klinické diagnostice bylo největší změnou opuštění vyšetřování tzv. citlivých bodů a použití novějších diagnostických kritérií. V medikamentózní léčbě se věnujeme zejména použití pregabalinu, duloxetinu a milnacipranu, jejich optimálnímu dávkování a nežádoucím účinkům. Mnoho významných odborníků se domnívá, že fibromylagie patří do rukou neurologů, a to nejen mechanismem vzniku, ale i používanými léky.

The article discusses new developments in fibromyalgia disease in terms of diagnosis, evaluation of clinical manifestation and treatment. The most important change is the elucidation of the pathophysiological mechanisms in the brain (nociplastic pain) that underlie the clinical manifestation of the symptoms, especially the widespread muscle and ligament pain. In clinical diagnosis, the biggest change has been the abandonment of the investigation of the so-called tender points and the use of newer diagnostic criteria. In drug therapy, we are particularly concerned with the use of pregabalin, duloxetine and milnacipran, their optimal dosage and side effects. Many eminent experts believe that the disease belongs in the hands of neurologists, not only in terms of the mechanism of origin, but also in terms of the treatment used, neurologists are best qualified to do so.

• MeSH
• Duloxetine Hydrochloride therapeutic use   MeSH
• Fibromyalgia * diagnosis   physiopathology   therapy   MeSH
• Humans MeSH
• Milnacipran therapeutic use   MeSH
• Pregabalin administration & dosage   therapeutic use   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Analgesics pharmacology   classification   therapeutic use   MeSH
• Antirheumatic Agents pharmacology   classification   therapeutic use   MeSH
• Axial Spondyloarthritis * complications   pathology   MeSH
• Pain * diagnosis   etiology   classification   MeSH
• Back Pain diagnosis   etiology   drug therapy   therapy   MeSH
• Diagnosis, Differential MeSH
• Fibromyalgia etiology   pathology   MeSH
• Humans MeSH
• Musculoskeletal Pain diagnosis   etiology   drug therapy   therapy   MeSH
• Osteoporosis complications   physiopathology   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Autoimmune Diseases * diagnosis   immunology   therapy   MeSH
• Hypersensitivity, Immediate diagnosis   etiology   therapy   MeSH
• Fibromyalgia diagnosis   etiology   therapy   MeSH
• Comorbidity MeSH
• Drug Hypersensitivity diagnosis   etiology   immunology   MeSH
• Humans MeSH
• Multimorbidity MeSH
• Fatigue Syndrome, Chronic diagnosis   etiology   therapy   MeSH
• Immunologic Deficiency Syndromes diagnosis   etiology   complications   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Chest Pain etiology   MeSH
• Diagnosis, Differential MeSH
• Hyperostosis, Diffuse Idiopathic Skeletal diagnostic imaging   pathology   therapy   MeSH
• Fibromyalgia diagnosis   etiology   pathology   therapy   MeSH
• Humans MeSH
• Musculoskeletal Diseases diagnostic imaging   classification   pathology   therapy   MeSH
• Spinal Diseases diagnostic imaging   physiopathology   pathology   therapy   MeSH
• Osteoporotic Fractures diagnostic imaging   drug therapy   pathology   MeSH
• Rheumatic Diseases * diagnostic imaging   classification   pathology   therapy   MeSH
• Arthritis, Rheumatoid diagnosis   etiology   drug therapy   pathology   MeSH
• Spondylarthritis diagnosis   complications   pathology   therapy   MeSH
• Lupus Erythematosus, Systemic diagnosis   drug therapy   physiopathology   pathology   MeSH
• Vasculitis classification   pathology   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH

Neinvazivní neuromodulační techniky ve světě zaujímají stále důležitější místo v léčbě bolestivých stavů, protože představují relativně bezpečnou a stále více dostupnou alternativu či doplnění farmakoterapie jejich akutních i chronických forem. Transkraniální stimulace stejnosměrným proudem (tDCS) je založena na neinvazivním využití bezpečné intenzity stejnosměrného proudu, který je aplikován pomocí stimulátoru s anodou a katodou eventuálně dalšími elektrodami umístěnými na hlavě, tak aby ve zvolené oblasti mozkové kůry vyvolal žádoucí změny excitability neuronů. Jednorázová aplikace tDCS ovlivňuje vylučování endogenních opioidů a opakované mají neuroplastické účinky, které lze výhodně využít například v kombinaci s rehabilitační praxí u bolestivých stavů pohybového aparátu (zlepšení pohybového učení). V článku čtenářům předkládáme kromě teoretické části přehled uplatnění tDCS u vybraných onemocnění spojených s bolestí, a to včetně některých poznámek týkajících se specifických zjištění, jež mohou zvýšit analgetický účinek tDCS.

Non-invasive neuromodulation techniques have recently received more attention in the treatment of both acute and chronic pain, as they represent a relatively safe and increasingly achievable alternative or complement to pharmacological interventions. Transcranial DC stimulation (tDCS) is based on the non-invasive use of a safe rate of direct current flow applied by a stimulator, usually to one anode and a cathode placed on the head, to induce desirable changes in neuronal excitability in a selected area of the cerebral cortex. Even a one-time application of tDCS affects the secretion of endogenous opioids, while multiple ones have a neuroplastic effect, which can be advantageously used, for example, in combination with rehabilitation practice for painful conditions of the musculoskeletal system (improvement of locomotor learning). In this article, we present an overview of the use of tDCS in selected pain-related diseases, including some notes on specific findings that may increase the analgesic effect of tDCS.

• MeSH
• Arthralgia therapy   MeSH
• Back Pain therapy   MeSH
• Electric Stimulation Therapy classification   methods   instrumentation   MeSH
• Phantom Limb therapy   MeSH
• Fibromyalgia therapy   MeSH
• Clinical Studies as Topic MeSH
• Knee Joint pathology   MeSH
• Combined Modality Therapy MeSH
• Humans MeSH
• Pain Management * methods   MeSH
• Migraine Disorders therapy   MeSH
• Neuralgia therapy   MeSH
• Facial Pain therapy   MeSH
• Transcranial Direct Current Stimulation * classification   methods   instrumentation   MeSH
• Rehabilitation MeSH
• Learning MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

Komplexní regionální bolestivý syndrom (KRBS) může vzniknout jako následek poranění periferního nervu. Fibromyalgie (FM) je onemocnění charakterizované difuzní bolestí, doprovázenou únavou, depresí, poruchami spánku a kognitivní dysfunkcí. Obě onemocnění se zařazují do kategorie tzv. nociplastické bolesti. Kazuistika popisuje 43letou pacientku trpící fibromyalgií, u které vznikl KRBS po operaci karpálního tunelu. V prosinci 2021 byla zavedena krční míšní stimulace. Po operaci došlo sice ke zmírnění úrovně bolesti pouze o 30 %, ale subjektivně k výraznému zlepšení kvality života, objektivně potvrzenému sérií psychologických testů. Míšní stimulace nepokryje celou oblast bolestivosti při fibromyalgii, nicméně pacientka je spokojená a difuzní bolest je nadále ovlivňována pomocí farmakoterapie spolu s lokálními obstřiky.

Complex regional pain syndrome (CRPS) can be caused by peripheral nerve injury. Fibromyalgia (FM) is sickness characterized by widespread pain accompanied with fatigue, depression, sleep disorders and cognitive impairment. Both disorders pertain to category of nociplastic pain. This case report describes 43-years-old woman suffered with fibromyalgia and CRPS following carpal tunnel surgery. A cervical spinal cord stimulation was introduced in December 2021. The pain relief was only 30% after surgery, nevertheless, she reported a significant improvement of quality of life, which was confirmed by series of psychological tests. Spinal cord stimulation does not cover whole area of diffuse pain caused by fibromyalgia, but the patient is satisfied and the therapy of the widespread pain still relies on pharmacotherapy and local injections.

• MeSH
• Adult MeSH
• Fibromyalgia diagnosis   therapy   MeSH
• Upper Extremity physiopathology   MeSH
• Complex Regional Pain Syndromes * diagnosis   therapy   MeSH
• Quality of Life MeSH
• Humans MeSH
• Spinal Cord Stimulation * MeSH
• Nociceptive Pain diagnosis   therapy   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• Keywords
• Digital Denture,
• MeSH
• Tooth Abnormalities complications   psychology   MeSH
• Alveoloplasty MeSH
• Computer-Aided Design MeSH
• Adult MeSH
• Tooth Extraction MeSH
• Fibromyalgia complications   MeSH
• Comorbidity MeSH
• Quality of Life MeSH
• Humans MeSH
• Software MeSH
• Oral Surgical Procedures MeSH
• Dentures * MeSH
• Dental Enamel pathology   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.

• MeSH
• Antioxidants metabolism   MeSH
• Biomarkers blood   MeSH
• Disulfides blood   MeSH
• Adult MeSH
• Fibromyalgia blood   physiopathology   MeSH
• Homeostasis * MeSH
• Middle Aged MeSH
• Humans MeSH
• Oxidative Stress physiology   MeSH
• Cross-Sectional Studies MeSH
• Sulfhydryl Compounds blood   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Journal Article MeSH