The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
30974173
DOI
10.1016/j.ejps.2019.04.003
PII: S0928-0987(19)30141-1
Knihovny.cz E-resources
- Keywords
- Absorption, Drug release, Food effect, Food-drug interaction, Metabolism, Oral bioavailability, Oral drug delivery,
- MeSH
- Administration, Oral MeSH
- Biological Availability MeSH
- Pharmacokinetics MeSH
- Gastrointestinal Absorption physiology MeSH
- Gastrointestinal Tract physiology MeSH
- Food-Drug Interactions physiology MeSH
- Intestinal Absorption MeSH
- Humans MeSH
- Drug Liberation physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Geographicals
- Europe MeSH
The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. In recent years, extensive efforts were made to elucidate the mechanisms that drive pharmacokinetic food-drug interactions. Their occurrence depends mainly on the properties of the drug substance, the formulation and a multitude of physiological factors. Every intake of food or drink changes the physiological conditions in the human gastrointestinal tract. Therefore, a precise understanding of how different foods and drinks affect the processes of drug absorption, distribution, metabolism and/or elimination as well as formulation performance is important in order to be able to predict and avoid such interactions. Furthermore, it must be considered that beverages such as milk, grapefruit juice and alcohol can also lead to specific food-drug interactions. In this regard, the growing use of food supplements and functional food requires urgent attention in oral pharmacotherapy. Recently, a new consortium in Understanding Gastrointestinal Absorption-related Processes (UNGAP) was established through COST, a funding organisation of the European Union supporting translational research across Europe. In this review of the UNGAP Working group "Food-Drug Interface", the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.
Medicines Evaluation Board in the Netherlands PKPD Department Utrecht the Netherlands
Medicines Evaluation Board in the Netherlands Quality Department Utrecht the Netherlands
University of Zagreb Faculty of Pharmacy and Biochemistry A Kovačića 1 10000 Zagreb Croatia
References provided by Crossref.org
