Absorption
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251 s. : il.
Práce zkoumá současné aplikační oblasti léčby hemoperfúzí (HP) v klinické medicíně na základě analýzy publikovaných prací registrovaných v systému Medline a nepublikovaných sdělení prezentovaných na mezinárodních nefrologlckých kongresech. Nejrozšířenější indikační oblastí jsou zóvožné akutní Intoxikace vyvolané sorpce schopnými léky, chemickými látkami a rostlinnými jedy. Z tzv. endogenních intoxikací má HP význam při eliminaci endotoxlnu a v komplexu opatření při náhradě funkce jater a ledvin. Slibné jsou výsledky s použitím specifických Imunosorbentů u imunologicky podmíněných onemocnění, u léčby hyperlipoprotelnemií a v transplantoční imunologii. Nově se zavádí technicky nenáročná metoda kontinuální arteriovenózní hemoperfúze. Sorpční hemoperfúze používoná v České republice při léčení závažných intoxikací příznivě ovlivňuje úroveň mortality.
The study sought to Identify current areas of use of hemoperfusion (HP) in clinical practice based on an analysis of papers published and indexed in Medline, and unpublished communications presented at international congresses of nephrology. The most widespread indication area includes severe acute intoxications due to absorbable drugs, chemicals, and plant toxins. As regards so colled endogenous intoxications, HP plays a role in eliminating endotoxin and as part of the precautions adopted when replacing the function of the liver and kidneys. Encouraging results have been reported with use of specific immunosorbents In Immunologlcally-medlated diseases, in the treatment of hyperlipoproteinemia, and in transplant immunology. A newcomer in the field is a technically undemanding method of continuous arterio-venous hemoperfusion. Absorption hemoperfusion, employed in the Czech Republic in the treatment of severe intoxications, has a beneficial effect of mortality rotes.
From a wide range of techniques appropriate to relate spectra measurements with soil properties, partial least squares (PLS) regression and support vector machines (SVM) are most commonly used. This is due to their predictive power and the availability of software tools. Both represent exclusively statistically based approaches and, as such, benefit from multiple responses of soil material in the spectrum. However, physical-based approaches that focus only on a single spectral feature, such as simple linear regression using selected continuum-removed spectra values as a predictor variable, often provide accurate estimates. Furthermore, if this approach extends to multiple cases by taking into account three basic absorption feature parameters (area, width, and depth) of all occurring features as predictors and subjecting them to best subset selection, one can achieve even higher prediction accuracy compared with PLS regression. Here, we attempt to further extend this approach by adding two additional absorption feature parameters (left and right side area), as they can be important diagnostic markers, too. As a result, we achieved higher prediction accuracy compared with PLS regression and SVM for exchangeable soil pH, slightly higher or comparable for dithionite-citrate and ammonium oxalate extractable Fe and Mn forms, but slightly worse for oxidizable carbon content. Therefore, we suggest incorporating the multiple linear regression approach based on absorption feature parameters into existing working practices.
Wiener klinische Wochenschrift, ISSN 0300-5178 98. Jahr., Suppl. 166, 1986
23 s. : tab., grafy ; 30 cm
