Risk factors for lethal arrhythmic events in children and adolescents with hypertrophic cardiomyopathy and an implantable defibrillator: An international multicenter study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
PubMed
31026510
DOI
10.1016/j.hrthm.2019.04.040
PII: S1547-5271(19)30369-8
Knihovny.cz E-zdroje
- Klíčová slova
- Arrhythmia, Children, Defibrillator, Hypertrophic cardiomyopathy, Sudden cardiac death,
- MeSH
- defibrilátory implantabilní * MeSH
- dětské nemocnice MeSH
- dítě MeSH
- echokardiografie metody MeSH
- elektrokardiografie metody MeSH
- hodnocení rizik MeSH
- hypertrofická kardiomyopatie komplikace diagnóza MeSH
- internacionalita MeSH
- Kaplanův-Meierův odhad MeSH
- kohortové studie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- náhlá srdeční smrt prevence a kontrola MeSH
- následné studie MeSH
- předškolní dítě MeSH
- proporcionální rizikové modely MeSH
- retrospektivní studie MeSH
- srdeční arytmie diagnostické zobrazování etiologie terapie MeSH
- stupeň závažnosti nemoci MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
BACKGROUND: Predictors of risk of lethal arrhythmic events (LAE) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). OBJECTIVE: The purpose of this study was to determine predictors of LAE in children with HCM. METHODS: A retrospective data collection was performed on 446 children and teenagers 20 years and younger (290 [65%] male; mean age 10.1 ± 5.7 years) with idiopathic HCM from 35 centers. Patients were classified as group 1 (HCM with LAE) if having a secondary prevention implantable cardioverter-defibrillator (ICD) or primary prevention ICD with appropriate interventions or group 2 (HCM without LAE) if having a primary prevention ICD without appropriate interventions. RESULTS: There were 152 children (34%) in group 1 and 294 (66%) in group 2. Risk factors for group 1 by univariate analysis were septal thickness, posterior left ventricular (LV) wall thickness, lower LV outflow gradient, and Q wave > 3 mm in inferior electrocardiographic leads. Factors not associated with LAE were family history of SCD, abnormal blood pressure response to exercise, and ventricular tachycardia on ambulatory electrocardiographic monitoring. Risk factors for SCD by multivariate analysis were age at ICD placement (hazard ratio [HR] 0.9; P = .0025), LV posterior wall thickness z score (HR 1.02; P < .005), and LV outflow gradient < 30 mm Hg (HR 2.0; P < .006). LV posterior wall thickness z score ≥ 5 was associated with LAE. CONCLUSION: Risk factors for LAE appear different in children compared to adults. Conventional adult risk factors were not significant in children. Further prospective studies are needed to improve risk stratification for LAE in children with HCM.
Advocate Hospital Chicago Illinois
C S Mott Children's Hospital Ann Arbor Michigan
Carolinas Health System Charlotte North Carolina
Children's Hospital of Los Angeles Los Angeles California
Children's Hospital of Michigan Detroit Michigan
Children's Hospital of Philadelphia Philadelphia Pennsylvania
Children's Hospital Omaha Nebraska
Cleveland Clinic Cleveland Ohio
Columbia University New York New York
German Heart Center Munich Germany
Hospital for Sick Kids Toronto Ontario Canada
Mercy Children's Hospital Kansas City Missouri
Montefiore Hospital New York New York
Motol University Prague Czech Republic
Nationwide Children's Hospital Columbus Ohio
Oregon Health and Science University Portland Oregon
Phoenix Children's Hospital Phoenix Arizona
Royal Children's Hospital Glasgow Scotland United Kingdom
Royal Children's Hospital Melbourne Australia
Saint Louis University Saint Louis Missouri
Sibley Heart Center Atlanta Georgia
University of Alberta Edmonton Alberta Canada
University of British Columbia Vancouver British Columbia Canada
University of California Irvine Irvine California
University of California Los Angeles Los Angeles California
University of California San Francisco San Francisco California
University of Cologne Cologne Germany
University of Colorado Denver Colorado
University of Iowa Iowa City Iowa
University of Montreal Montreal Quebec Canada
University of Texas Southwestern Dallas Texas
University of Utah Salt Lake City Utah
University of Virginia Charlottesville Virginia
Vanderbilt University Nashville Tennessee
Zucker School of Medicine at Hofstra Northwell Hempstead New York
Citace poskytuje Crossref.org
Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy
