Brain volumetric correlates of dysarthria in multiple sclerosis
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31102976
DOI
10.1016/j.bandl.2019.04.009
PII: S0093-934X(18)30114-7
Knihovny.cz E-resources
- Keywords
- Acoustic analyses, Brain atrophy, Dysarthria, MRI, Morphometry, Multiple sclerosis, Speech,
- MeSH
- Atrophy diagnostic imaging MeSH
- Reading MeSH
- Adult MeSH
- Dysarthria diagnostic imaging etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain diagnostic imaging pathology MeSH
- Multiple Sclerosis complications diagnostic imaging MeSH
- Gray Matter diagnostic imaging pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Although dysarthria is a common pattern in multiple sclerosis (MS), the contribution of specific brain areas to key factors of dysarthria remains unknown. Speech data were acquired from 123 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6.5 and 60 matched healthy controls. Results of computerized acoustic analyses of subtests on spastic and ataxic aspects of dysarthria were correlated with MRI-based brain volume measurements. Slow articulation rate during reading was associated with bilateral white and grey matter loss whereas reduced maximum speed during oral diadochokinesis was related to greater cerebellar involvement. Articulation rate showed similar correlation to whole brain atrophy (r = 0.46, p < 0.001) as the standard clinical scales such as EDSS (r = -0.45, p < 0.001). Our results support the critical role of the pyramidal tract and cerebellum in the modification of motor speech timing in MS.
References provided by Crossref.org
Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease
