Environmental pollutants, including antibiotics (ATBs), have become an increasingly common health hazard in the last several decades. Overdose and abuse of ATBs led to the emergence of antibiotic-resistant genes (ARGs), which represent a serious health threat. Moreover, water bodies and reservoirs are places where a wide range of bacterial species with ARGs originate, owing to the strong selective pressure from presence of ATB residues. In this regard, graphene oxide (GO) has been utilised in several fields including remediation of the environment. In this review, we present a brief overview of resistant genes of frequently used ATBs, their occurrence in the environment and their behaviour. Further, we discussed the factors influencing the binding of nucleic acids and the response of ARGs to GO, including the presence of salts in the water environment or water pH, because of intrinsic properties of GO of not only binding to nucleic acids but also catalysing their decomposition. This would be helpful in designing new types of water treatment facilities.

Central European Institute of Technology Brno University of Technology Purkynova 656 123 612 00 Brno Czech Republic

Department of Chemistry and Biochemistry Mendel University in Brno Zemedelska 1 613 00 Brno Czech Republic

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Basic Life Sci. 1975;5A:355-67 PubMed

Ann Med. 2001 Apr;33(3):167-71 PubMed

Water Res. 2002 Apr;36(8):1955-64 PubMed

Biochemistry. 2002 Nov 26;41(47):13851-60 PubMed

Water Res. 2003 Apr;37(7):1443-67 PubMed

Am J Infect Control. 2003 Apr;31(2):124-7 PubMed

Water Res. 2003 Apr;37(8):1685-90 PubMed

J Antimicrob Chemother. 2003 Aug;52(2):159-61 PubMed

FEMS Microbiol Lett. 1992 Jun 1;72(2):195-8 PubMed

J Antimicrob Chemother. 2004 Aug;54(2):311-20 PubMed

Trends Microbiol. 2004 Sep;12(9):412-6 PubMed

Science. 2005 Jun 10;308(5728):1635-8 PubMed

Chem Commun (Camb). 2005 May 28;(20):2540-8 PubMed

Environ Sci Technol. 2005 May 15;39(10):3421-9 PubMed

PLoS Biol. 2005 Jul;3(7):e255 PubMed

Sci Total Environ. 2006 Aug 1;366(2-3):772-83 PubMed

Phys Rev Lett. 2005 Oct 28;95(18):186101 PubMed

Cell. 2006 Feb 24;124(4):837-48 PubMed

Environ Sci Technol. 2006 Dec 1;40(23):7445-50 PubMed

Nat Mater. 2007 Mar;6(3):183-91 PubMed

FEMS Microbiol Rev. 2007 Jul;31(4):449-77 PubMed

J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):559-73 PubMed

Phys Chem Chem Phys. 2008 May 21;10(19):2722-9 PubMed

Chemosphere. 2008 Jun;72(6):968-73 PubMed

Curr Opin Biotechnol. 2008 Jun;19(3):260-5 PubMed

Environ Int. 2008 Nov;34(8):1215-26 PubMed

Nat Nanotechnol. 2007 May;2(5):295-300 PubMed

Nat Nanotechnol. 2008 May;3(5):270-4 PubMed

Expert Rev Anti Infect Ther. 2008 Oct;6(5):725-32 PubMed

Int J Antimicrob Agents. 2009 Feb;33(2):125-9 PubMed

Nat Nanotechnol. 2009 Jan;4(1):25-9 PubMed

Annu Rev Biochem. 2009;78:119-46 PubMed

Appl Environ Microbiol. 2009 Sep;75(17):5714-8 PubMed

Nat Nanotechnol. 2009 Jul;4(7):441-4 PubMed

FEMS Microbiol Ecol. 2003 Apr 1;43(3):325-35 PubMed

Langmuir. 2010 Feb 16;26(4):2618-23 PubMed

Res Microbiol. 2010 Jan-Feb;161(1):58-66 PubMed

Environ Pollut. 2010 May;158(5):1444-50 PubMed

Chem Rev. 2010 Feb 10;110(2):1018-59 PubMed

Nat Rev Microbiol. 2010 Apr;8(4):251-9 PubMed

Nano Lett. 2010 Apr 14;10(4):1144-8 PubMed

Nano Res. 2008;1(3):203-212 PubMed

Environ Pollut. 2010 Jul;158(7):2350-8 PubMed

Water Res. 2010 Aug;44(15):4295-323 PubMed

Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33 PubMed

Water Res. 2011 Jan;45(2):681-93 PubMed

ACS Nano. 2010 Dec 28;4(12):7169-74 PubMed

Chem Commun (Camb). 2011 Apr 14;47(14):4055-61 PubMed

Langmuir. 2011 Mar 15;27(6):2731-8 PubMed

Trends Biotechnol. 2011 May;29(5):205-12 PubMed

Trends Ecol Evol. 2011 Jun;26(6):278-84 PubMed

ACS Nano. 2011 Jun 28;5(6):4401-6 PubMed

J Colloid Interface Sci. 2011 Sep 1;361(1):270-7 PubMed

Adv Mater. 2011 Sep 8;23(34):3959-63 PubMed

ACS Nano. 2011 Sep 27;5(9):6971-80 PubMed

Nature. 2011 Aug 31;477(7365):457-61 PubMed

Water Res. 2011 Nov 1;45(17):5599-611 PubMed

Clin Microbiol Rev. 2011 Oct;24(4):718-33 PubMed

J Colloid Interface Sci. 2012 Feb 15;368(1):540-6 PubMed

Front Microbiol. 2012 Jan 26;3:18 PubMed

ACS Nano. 2012 Apr 24;6(4):2904-16 PubMed

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4944-9 PubMed

J Environ Monit. 2012 Jul;14(7):1754-71 PubMed

Phys Chem Chem Phys. 2012 Aug 14;14(30):10485-96 PubMed

Environ Sci Technol. 2012 Sep 4;46(17):9716-26 PubMed

Biomaterials. 2012 Nov;33(32):8017-25 PubMed

Small. 2013 Jan 28;9(2):273-83 PubMed

Clin Microbiol Rev. 2012 Oct;25(4):661-81 PubMed

Chem Soc Rev. 2013 Jan 21;42(2):530-47 PubMed

Nature. 2012 Oct 11;490(7419):192-200 PubMed

PLoS One. 2012;7(11):e48325 PubMed

Appl Environ Microbiol. 2013 Feb;79(3):835-44 PubMed

Water Res. 2013 Apr 1;47(5):1875-87 PubMed

Sci Total Environ. 2013 Mar 1;447:345-60 PubMed

Environ Sci Technol. 2013 Mar 19;47(6):2892-7 PubMed

Nanoscale. 2013 Apr 21;5(8):3149-71 PubMed

Front Microbiol. 2013 Apr 30;4:103 PubMed

J Environ Qual. 2013 Jan-Feb;42(1):191-8 PubMed

Water Res. 2013 Sep 1;47(13):4621-9 PubMed

Water Environ Res. 2013 May;85(5):411-21 PubMed

Environ Sci Technol. 2013 Aug 6;47(15):8157-63 PubMed

J Hazard Mater. 2013 Dec 15;263 Pt 2:467-78 PubMed

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19860-5 PubMed

Langmuir. 2013 Dec 10;29(49):15174-81 PubMed

Environ Sci Technol. 2014;48(1):71-8 PubMed

Nanotechnology. 2014 Apr 25;25(16):165101 PubMed

Angew Chem Int Ed Engl. 2014 Jul 1;53(27):6929-32 PubMed

Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:288-98 PubMed

Environ Sci Technol. 2014 Jul 15;48(14):7683-9 PubMed

Infect Drug Resist. 2014 Jun 20;7:167-76 PubMed

Water Res. 2015 Feb 1;69:234-242 PubMed

Dalton Trans. 2015 Feb 7;44(5):2299-310 PubMed

Nat Rev Microbiol. 2015 Feb;13(2):116-23 PubMed

Nanotoxicology. 2015;9(7):895-904 PubMed

Science. 2015 Feb 13;347(6223):704 PubMed

PLoS One. 2015 Mar 04;10(3):e0119403 PubMed

ACS Appl Mater Interfaces. 2015 May 20;7(19):10576-86 PubMed

Chemosphere. 2015 Oct;136:20-6 PubMed

Chem Rev. 2015 Jun 10;115(11):4744-822 PubMed

Environ Sci Technol. 2015 Jul 21;49(14):8396-407 PubMed

Environ Sci Technol. 2015 Jul 21;49(14):8416-24 PubMed

Adv Funct Mater. 2015 Feb 11;25(6):936-946 PubMed

ACS Nano. 2016 Jan 26;10(1):274-9 PubMed

J Org Chem. 2016 Jan 15;81(2):351-9 PubMed

Euro Surveill. 2015;20(46):null PubMed

Nanoscale. 2016 Jan 7;8(1):117-9 PubMed

Environ Sci Technol. 2016 Mar 15;50(6):3193-201 PubMed

Nanotoxicology. 2016 Oct;10(8):1051-60 PubMed

Environ Sci Pollut Res Int. 2016 Jul;23(14):13754-88 PubMed

Nanoscale Res Lett. 2016 Dec;11(1):211 PubMed

Analyst. 2016 Jun 20;141(13):4029-34 PubMed

J Chem Phys. 2016 Jun 14;144(22):225102 PubMed

Crit Care. 2016 Jun 22;20(1):136 PubMed

Sci Rep. 2016 Jul 22;6:30237 PubMed

PLoS Biol. 2016 Aug 19;14(8):e1002533 PubMed

ACS Infect Dis. 2015 Feb 13;1(2):80-4 PubMed

Environ Sci Technol. 2016 Nov 1;50(21):11862-11871 PubMed

ACS Appl Mater Interfaces. 2016 Dec 7;8(48):33165-33174 PubMed

Chemosphere. 2017 Sep;183:197-203 PubMed

Sci Total Environ. 2018 Jan 15;612:788-798 PubMed

Environ Pollut. 2017 Dec;231(Pt 1):829-836 PubMed

Sci Total Environ. 2018 Jan 15;612:1300-1310 PubMed

Environ Pollut. 2018 Feb;233:1049-1057 PubMed

Sci Total Environ. 2018 Apr 15;621:1176-1184 PubMed

J Hazard Mater. 2018 Feb 15;344:441-449 PubMed

Sci Total Environ. 2018 Mar;616-617:453-461 PubMed

J Hazard Mater. 2018 Feb 15;344:716-722 PubMed

Microb Drug Resist. 2018 Jun;24(5):542-546 PubMed

Front Microbiol. 2017 Nov 16;8:2200 PubMed

Bioresour Technol. 2018 Apr;253:235-243 PubMed

Sci Total Environ. 2018 Jun 1;626:835-841 PubMed

Water Res. 2018 May 1;134:126-139 PubMed

Microb Pathog. 2018 Mar;116:241-245 PubMed

Environ Pollut. 2018 May;236:126-136 PubMed

J Hazard Mater. 2018 May 15;350:10-18 PubMed

Environ Pollut. 2018 May;236:734-744 PubMed

Nanoscale. 2018 Mar 1;10(9):4475-4487 PubMed

Sci Total Environ. 2018 Jul 15;630:117-125 PubMed

Environ Int. 2018 May;114:87-94 PubMed

Environ Sci Pollut Res Int. 2018 May;25(14):13956-13963 PubMed

J Environ Manage. 2018 May 15;214:149-156 PubMed

Mar Pollut Bull. 2018 Mar;128:475-482 PubMed

Environ Pollut. 2018 Jul;238:291-298 PubMed

Ecotoxicol Environ Saf. 2018 Aug 15;157:169-175 PubMed

Int J Environ Res Public Health. 2018 Apr 10;15(4): PubMed

Environ Int. 2018 Aug;117:107-115 PubMed

Environ Sci Technol. 2018 Jun 5;52(11):6113-6125 PubMed

Sci Total Environ. 2018 Feb 15;615:1332-1340 PubMed

Microb Drug Resist. 2018 May 24;:null PubMed

J Microbiol. 2018 Jun;56(6):408-415 PubMed

Front Microbiol. 2018 Jun 28;9:1283 PubMed

Toxicology. 2018 Dec 1;410:83-95 PubMed

Front Microbiol. 2018 Oct 16;9:2502 PubMed

J Am Chem Soc. 1968 Dec 18;90(26):7323-8 PubMed

Antimicrob Agents Chemother. 1994 Jul;38(7):1447-51 PubMed

Curr Opin Struct Biol. 1998 Feb;8(1):54-63 PubMed

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6578-83 PubMed

CMAJ. 1998 Nov 3;159(9):1129-36 PubMed