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Poly-ε-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits

Buzgo, Matej
Author Buzgo, Matej Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Plencner, Martin
Author Plencner, Martin Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
Rampichova, Michala
Author Rampichova, Michala Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Litvinec, Andrej
Author Litvinec, Andrej Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
Prosecka, Eva
Author Prosecka, Eva Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
Staffa, Andrea
Author Staffa, Andrea Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Kralovic, Martin
Author Kralovic, Martin Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Filova, Eva
Author Filova, Eva Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
Doupnik, Miroslav
Author Doupnik, Miroslav Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Lukasova, Vera
Author Lukasova, Vera Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Vocetkova, Karolina
Author Vocetkova, Karolina Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Anderova, Jana
Author Anderova, Jana Department of Anatomy & Biomechanics, Faculty of Physical Education & Sport, Charles University, Jose Martiho 31, 162 52 Prague 6, Czech Republic
Kubikova, Tereza
Author Kubikova, Tereza Biomedical Center and Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 00 Pilsen, Czech Republic
Zajicek, Robert
Author Zajicek, Robert Department of Burns Medicine, 3rd Faculty of Medicine, University Hospital Kralovske Vinohrady, Srobarova 1150/50, 100 00 Prague 10, Czech Republic
Lopot, Frantisek
Author Lopot, Frantisek Department of Anatomy & Biomechanics, Faculty of Physical Education & Sport, Charles University, Jose Martiho 31, 162 52 Prague 6, Czech Republic
Jelen, Karel
Author Jelen, Karel Department of Anatomy & Biomechanics, Faculty of Physical Education & Sport, Charles University, Jose Martiho 31, 162 52 Prague 6, Czech Republic
Tonar, Zbynek
Author Tonar, Zbynek Biomedical Center and Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 00 Pilsen, Czech Republic
Amler, Evzen
Author Amler, Evzen Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic Nanoprogres, z.s.p.o., Nova 306, 530 09 Pardubice, Czech Republic
Divin, Radek
Author Divin, Radek Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic
Fiori, Fabrizio
Author Fiori, Fabrizio Universita Politecnica delle Marche, Di.S.C.O., Via Brecce Bianche, 60131 Ancona, Italy

Regenerative medicine. 2019 May ; 14 (5) : 423-445. [epub] 20190610

Regen Med
ISSN 1746-076X | 1746-0751
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid31180294

PubMed 31180294
DOI 10.2217/rme-2018-0072
Knihovny.cz E-resources

Keywords
electrospinning, nanofibers, polycaprolactone, polyvinyl alcohol, wound healing,
MeSH
3T3 Cells MeSH
Wound Healing drug effects MeSH
Rabbits MeSH
Skin * injuries metabolism pathology MeSH
Mice MeSH
Nanofibers chemistry MeSH
Bandages * MeSH
Polyesters * chemistry pharmacology MeSH
Polyvinyl Alcohol chemistry pharmacology MeSH
Swine MeSH
Tissue Adhesives * chemistry pharmacology MeSH
Animals MeSH
Check Tag
Rabbits MeSH
Mice MeSH
Animals MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
polycaprolactone MeSH Browser
Polyesters * MeSH
Polyvinyl Alcohol MeSH
Tissue Adhesives * MeSH

Aim: This study evaluates the effect of electrospun dressings in critical sized full-thickness skin defects in rabbits. Materials & methods: Electrospun poly-ε-caprolactone (PCL) and polyvinyl alcohol (PVA) nanofibers were tested in vitro and in vivo. Results: The PCL scaffold supported the proliferation of mesenchymal stem cells, fibroblasts and keratinocytes. The PVA scaffold showed significant swelling, high elongation capacity, limited protein adsorption and stimulation of cells. Nanofibrous dressings improved wound healing compared with the control group in vivo. A change of the PCL dressing every 7 days resulted in a decreased epithelial thickness and type I collagen level in the adhesive group, indicating peeling off of the newly formed tissue. In the PVA dressings, the exchange did not affect healing. Conclusion: The results demonstrate the importance of proper dressing exchange.

Biomedical Center and Department of Histology and Embryology Faculty of Medicine in Pilsen Charles University Husova 3 301 00 Pilsen Czech Republic

Department of Anatomy and Biomechanics Faculty of Physical Education and Sport Charles University Jose Martiho 31 162 52 Prague 6 Czech Republic

Department of Biophysics 2nd Faculty of Medicine Charles University 5 Uvalu 84 150 06 Prague 5 Czech Republic

Department of Burns Medicine 3rd Faculty of Medicine University Hospital Kralovske Vinohrady Srobarova 1150 50 100 00 Prague 10 Czech Republic

Laboratory of Advanced Biomaterials University Centre for Energy Efficient Buildings Czech Technical University Trinecka 1024 273 43 Bustehrad Czech Republic

Laboratory of Tissue Engineering Institute of Experimental Medicine of the Czech Academy of Sciences Videnska 1083 142 20 Prague 4 Czech Republic

Nanoprogres z s p o Nova 306 530 09 Pardubice Czech Republic

Universita Politecnica delle Marche Di S C O Via Brecce Bianche 60131 Ancona Italy

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