Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release
Jazyk angličtina Země Polsko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
31259696
DOI
10.2478/acph-2018-0030
PII: /j/acph.2018.68.issue-3/acph-2018-0030/acph-2018-0030.xml
Knihovny.cz E-zdroje
- Klíčová slova
- coprocessed dry binder, dissolution testing, energy profile of compression, matrix tablets, polyvinyl alcohol, tensile strength of tablets,
- MeSH
- celulosa chemie MeSH
- farmaceutická chemie metody MeSH
- farmaceutická technologie metody MeSH
- kyselina salicylová aplikace a dávkování chemie MeSH
- laktosa chemie MeSH
- nelineární dynamika MeSH
- pevnost v tahu MeSH
- polyvinylalkohol chemie MeSH
- pomocné látky chemie MeSH
- rozpustnost MeSH
- tablety MeSH
- uvolňování léčiv MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- celulosa MeSH
- kyselina salicylová MeSH
- laktosa MeSH
- microcrystalline cellulose MeSH Prohlížeč
- polyvinylalkohol MeSH
- pomocné látky MeSH
- tablety MeSH
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.
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