GFP transgenic animals in biomedical research: a review of potential disadvantages
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
31342754
DOI
10.33549/physiolres.934227
PII: 934227
Knihovny.cz E-zdroje
- MeSH
- biomedicínský výzkum metody trendy MeSH
- dánio pruhované MeSH
- geneticky modifikovaná zvířata genetika MeSH
- králíci MeSH
- myši transgenní MeSH
- myši MeSH
- vývojová regulace genové exprese MeSH
- zelené fluorescenční proteiny biosyntéza genetika MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- zelené fluorescenční proteiny MeSH
Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals' health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.
Citace poskytuje Crossref.org
