The uptake, effects and biotransformation of monepantel in meadow plants used as a livestock feed
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31374394
DOI
10.1016/j.chemosphere.2019.124434
PII: S0045-6535(19)31655-8
Knihovny.cz E-zdroje
- MeSH
- aminoacetonitrily analogy a deriváty farmakokinetika toxicita MeSH
- anthelmintika toxicita MeSH
- biologický transport MeSH
- biotransformace MeSH
- dobytek MeSH
- krmivo pro zvířata toxicita MeSH
- Medicago sativa metabolismus MeSH
- metabolické sítě a dráhy MeSH
- pastviny * MeSH
- Plantago metabolismus MeSH
- sulfony MeSH
- tandemová hmotnostní spektrometrie MeSH
- znečištění životního prostředí * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aminoacetonitrily MeSH
- anthelmintika MeSH
- monepantel sulfone MeSH Prohlížeč
- monepantel MeSH Prohlížeč
- sulfony MeSH
Drugs are potentially dangerous environmental contaminants, as they are designed to have biological effects at low concentrations. Monepantel (MOP), an amino-acetonitrile derivative, is frequently used veterinary anthelmintics, but information about MOP environmental circulation and impact is almost non-existent. We studied the phytotoxicity, uptake and biotransformation of MOP in two fodder plants, Plantago lanceolata and Medicago sativa. The seeds and whole plant regenerants were cultivated with MOP. The plant roots and the leaves were collected after 1, 2, 3, 4, 5 and 6 weeks of cultivation. The lengths of roots and proline concentrations in the roots and leaves were measured to evaluate MOP phytotoxicity. The UHPLC-MS/MS technique with a Q-TOF mass analyser was used for the identification and semi-quantification of MOP and its metabolites. Our results showed no phytotoxicity of MOP. However, both plants were able to uptake, transport and metabolize MOP. Comparing both plants, the uptake of MOP was much more extensive in Medicago sativa (almost 10-times) than in Plantago lanceolate. Moreover, 9 various metabolites of MOP were detected in Medicago sativa, while only 7 MOP metabolites were found in Plantago lanceolata. Based on metabolites structures, scheme of the metabolic pathways of MOP in both plants was proposed. MOP and its main metabolite (MOP sulfone), both anthelmintically active, were present not only in roots but also in leaves that can be consumed by animals. This indicates the potential for undesirable circulation of MOP in the environment, which could lead to many pharmacological and toxicological consequences.
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