Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31402190
DOI
10.1016/j.dci.2019.103464
PII: S0145-305X(19)30092-8
Knihovny.cz E-resources
- Keywords
- Avian schistosome, Encapsulation, Haemocytes, Lymnaea stagnalis, Phagocytosis, Trichobilharzia szidati,
- MeSH
- Hemocytes immunology parasitology MeSH
- Immunomodulation MeSH
- Trematode Infections parasitology transmission MeSH
- Host-Parasite Interactions immunology MeSH
- Humans MeSH
- Lymnaea immunology parasitology MeSH
- Schistosomatidae physiology MeSH
- Signal Transduction immunology MeSH
- Life Cycle Stages MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Lymnaea stagnalis is a common freshwater gastropod. Importantly, the snail serves as the intermediate host for more than one hundred species of digenetic trematodes, including the avian schistosome Trichobilharzia szidati, a causative agent of cercarial dermatitis in humans. Infection of L. stagnalis by T. szidati initiates a dynamic confrontation between the host and the parasite that culminates in immunocompatibility ensuring survival and development of larvae. Unfortunately, the molecular mechanisms determining this immunocompatibility remain poorly characterised. By employing a variety of immune elicitors, including chemical compounds, PAMPs and bacteria, research in the last two decades has elucidated some of the molecular processes that regulate the snail internal defence response such as haemocyte signalling pathways. These discoveries provide a framework for future studies of molecular interactions between T. szidati and L. stagnalis to help elucidate factors and mechanisms enabling transmission of schistosome parasites. Moreover, support from recently available next generation sequence data and CRISPR-enabled functional genomics should further enable L. stagnalis as an important model for comparative immunology and contribute to a more comprehensive understanding of immune functions in gastropod molluscs.
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