Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
31492387
DOI
10.1016/j.tvjl.2019.105350
PII: S1090-0233(19)30083-8
Knihovny.cz E-zdroje
- Klíčová slova
- Canine Cushing’s, Cholecystectomy, Gallbladder mucocoele, Hypothyroidism, Survival,
- MeSH
- adrenokortikální hyperfunkce veterinární MeSH
- bilirubin krev MeSH
- biologické markery MeSH
- genetická predispozice k nemoci MeSH
- hyperbilirubinemie veterinární MeSH
- hyperlipidemie veterinární MeSH
- mukokéla diagnóza mortalita chirurgie veterinární MeSH
- nemoci psů diagnóza mortalita chirurgie MeSH
- nemoci žlučníku diagnóza mortalita chirurgie veterinární MeSH
- psi MeSH
- retrospektivní studie MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Názvy látek
- bilirubin MeSH
- biologické markery MeSH
Gallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7 to 45%. Therefore, the aim of this study was to identify the association of survival with variables that could be utilized to improve clinical decisions. A total of 1194 dogs with a gross and histopathological diagnosis of GBM were included from 41 veterinary referral hospitals in this retrospective study. Dogs with GBM that demonstrated abnormal clinical signs had significantly greater odds of death than subclinical dogs in a univariable analysis (OR, 4.2; 95% CI, 2.14-8.23; P<0.001). The multivariable model indicated that categorical variables including owner recognition of jaundice (OR, 2.12; 95% CI, 1.19-3.77; P=0.011), concurrent hyperadrenocorticism (OR 1.94; 95% CI, 1.08-3.47; P=0.026), and Pomeranian breed (OR, 2.46; 95% CI 1.10-5.50; P=0.029) were associated with increased odds of death, and vomiting was associated with decreased odds of death (OR, 0.48; 95% CI, 0.30-0.72; P=0.001). Continuous variables in the multivariable model, total serum/plasma bilirubin concentration (OR, 1.03; 95% CI, 1.01-1.04; P<0.001) and age (OR, 1.17; 95% CI, 1.08-1.26; P<0.001), were associated with increased odds of death. The clinical utility of total serum/plasma bilirubin concentration as a biomarker to predict death was poor with a sensitivity of 0.61 (95% CI, 0.54-0.69) and a specificity of 0.63 (95% CI, 0.59-0.66). This study identified several prognostic variables in dogs with GBM including total serum/plasma bilirubin concentration, age, clinical signs, concurrent hyperadrenocorticism, and the Pomeranian breed. The presence of hypothyroidism or diabetes mellitus did not impact outcome in this study.
Bryanston Veterinary Hospital P O Box 67092 Bryanston South Africa
Department of Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL 36849 USA
Department of Veterinary Medicine University of Cambridge Cambridge CB3 0ES United Kingdom
Pride Veterinary Centre Riverside Road Pride Park Derby UK
San Marco Veterinary Clinic via Sorio 114c 35141 Padua Italy
School of Veterinary Science Massey University Palmerston North 4410 New Zealand
Small Animal Department Faculty of Veterinary Medicine Ghent University Merelbeke Belgium
University of Glasgow Small Animal Hospital Bearsden Road Glasgow G61 1QH United Kingdom
Vet Support Small Animal Intensive Care Medicine Sao Paulo 04082 002 Brazil
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