Determinants of utilization of cryopreservation of germ cells in adolescent cancer patients in four European countries

. 2020 Jan ; 179 (1) : 51-60. [epub] 20190907

Jazyk angličtina Země Německo Médium print-electronic

Typ dokumentu klinické zkoušky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid31493021

Grantová podpora
602030 European Union's Seventh Framework Programme for research, technological development and demonstration; PanCareLIFE WP2b
EKPS201607 Berliner Krebsgesellschaft

Odkazy

PubMed 31493021
DOI 10.1007/s00431-019-03459-9
PII: 10.1007/s00431-019-03459-9
Knihovny.cz E-zdroje

Infertility is a relevant late-effect following cancer treatment; yet, a large proportion of survivors cannot recall having been informed of this risk. In an intervention study, we examined if and how supportive patient information material on fertility/fertility-preserving measures influences utilization of cryopreservation in adolescent cancer patients. The control group, recruited 03/2014-01/2016, received the usual patient education at initial diagnosis. The intervention group, recruited 04/2016-10/2017, received patient education supported by a fertility flyer and brochure. Patients and parents were each asked questions on utilization of cryopreservation in a questionnaire 3 and 6 months after initial diagnosis. Patient core and therapy data were obtained from medical records. Overall, cryopreservation rates showed no significant difference between the control (32.7%, n = 37/113) and intervention group (36.6%, n = 37/101). In the control group, cryopreservation was associated with gender (OR 0.100, CI 0.023-0.427), age (OR 1.559, CI 1.077-2.258) and recalling information on fertility protection (OR 33.663, CI 2.100-539.574); in the intervention group, cryopreservation was related to gender (OR 0.093, CI 0.026-0.330) and the estimated infertility risk (OR 43.665, CI 2.157-883.974).Conclusion: Cryopreservation rates did not overall increase following the intervention; however, the individual risk seemed to be brought into attention more: Those at risk, including younger patients, cryopreserved at higher rates.What is Known:•Infertility is a relevant late-effect following adolescent cancer.•Guidelines recommend to offer fertility protection before cancer treatment.•A relevant proportion of adolescents with cancer are not aware of this risk.•Fertility protection seems under-used in cancer patients at risk for infertility.What is New:•Information material on fertility and protection in adolescents did not increase overall rates of cryopreservation.•Cryopreservation rates were improved according to individual risk for infertility.•Our flyers and brochures on fertility in cancer patients are available in various languages.

Zobrazit více v PubMed

Behav Res Methods. 2009 Nov;41(4):1149-60 PubMed

JCO Glob Oncol. 2020 Mar 2;6: PubMed

Cell J. 2017 Jul-Sep;19(2):173-183 PubMed

Hum Reprod Open. 2017 Mar 29;2017(1):hox003 PubMed

Eur J Cancer Care (Engl). 2020 Sep;29(5):e13279 PubMed

Psychooncology. 2004 Oct;13(10):689-99 PubMed

Can Urol Assoc J. 2017 Jan-Feb;11(1-2Suppl1):S97-S102 PubMed

N Engl J Med. 2017 Oct 26;377(17):1657-1665 PubMed

J Adolesc Health. 2017 Mar;60(3):277-283 PubMed

Reprod Biomed Online. 2016 Jul;33(1):29-38 PubMed

N Engl J Med. 2005 Jul 7;353(1):64-73 PubMed

Lancet Oncol. 2017 Feb;18(2):e75-e90 PubMed

Bull Tokyo Med Dent Univ. 1976 Dec;23(4):203-10 PubMed

J Psychosoc Oncol. 2011;29(3):274-85 PubMed

J Cancer Surviv. 2007 Jun;1(2):146-55 PubMed

Pediatr Hematol Oncol. 1999 Sep-Oct;16(5):459-62 PubMed

Klin Padiatr. 2018 Feb 08;: PubMed

Cancer. 2018 Sep 1;124(17):3567-3575 PubMed

Geburtshilfe Frauenheilkd. 2018 Jun;78(6):567-584 PubMed

Fertil Steril. 2015 Feb;103(2):478-86.e1 PubMed

Eur J Cancer Care (Engl). 2019 Jan;28(1):e12947 PubMed

Eur J Cancer. 2018 Nov;103:227-237 PubMed

J Clin Pathol. 1980 Aug;33(8):722-9 PubMed

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