Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31526572
DOI
10.1016/j.jelectrocard.2019.09.001
PII: S0022-0736(19)30415-7
Knihovny.cz E-resources
- Keywords
- Implantable cardioverter defibrillator, Mortality, Risk factors, Sudden cardiac death,
- MeSH
- Defibrillators, Implantable * MeSH
- Electrocardiography MeSH
- Humans MeSH
- Multicenter Studies as Topic MeSH
- Death, Sudden, Cardiac * prevention & control MeSH
- Observational Studies as Topic MeSH
- Prospective Studies MeSH
- Comparative Effectiveness Research * MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Geographicals
- Europe MeSH
BACKGROUND: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients who benefit from prophylactic ICD therapy. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) completed in 2019 will assess this issue. SUMMARY: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicenter observational cohort study done in 44 centers across 15 European countries. A total of 2327 patients with heart failure due to ischemic heart disease or dilated cardiomyopathy indicated for primary prophylactic ICD implantation were recruited between 2014 and 2018 (>1500 patients at first ICD implantation, >750 patients non-randomized non-ICD control group). The primary endpoint was all-cause mortality, and first appropriate shock was co-primary endpoint. At baseline, all patients underwent 12‑lead ECG and Holter-ECG analysis using multiple advanced methods for risk stratification as well as documentation of clinical characteristics and laboratory values. The EU-CERT-ICD data will provide much needed information on the survival benefit of preventive ICD therapy and expand on previous prospective risk stratification studies which showed very good applicability of clinical parameters and advanced risk stratifiers in order to define patient subgroups with above or below average ICD benefit. CONCLUSION: The EU-CERT-ICD study will provide new and current data about effectiveness of primary prophylactic ICD implantation. The study also aims for improved risk stratification and patient selection using clinical risk markers in general, and advanced ECG risk markers in particular.
2nd Dept of Cardiology Attikon University Hospital Athens Greece
Chair and Dept of Cardiology Bieganski Hospital Medical University of Lodz Lodz Poland
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Dept of Cardiology Acibadem City Clinic Tokuda Hospital Sofia Bulgaria
Dept of Cardiology and Pneumology Heart Center University Medical Center Göttingen Germany
Dept of Cardiology KBC Sestre Milosrdnice Zagreb Croatia
Dept of Cardiology Klinikum Großhadern Ludwig Maximilians Universität Munich Germany
Dept of Cardiology Magdalena Klinika Krapinske Toplice Croatia
Dept of Cardiology Medical University of Lodz CKD Hospital Lodz Poland
Dept of Cardiology Medical University of Lodz WAM Hospital Lodz Poland
Dept of Cardiology National Heart Hospital Sofia Bulgaria
Dept of Cardiology St Anna Hospital Sofia Bulgaria
Dept of Cardiology St Ekaterina University Hospital Sofia Bulgaria
Dept of Cardiology SUSSCH Banska Bystrica Slovakia
Dept of Cardiovascular Disease KBC Rijeka Rijeka Croatia
Dept of Medical Physiology University Medical Center Utrecht Netherlands
Dept of Medical Statistics University Medical Center Göttingen Göttingen Germany
Gentofte Hospital Copenhagen Denmark
Heart and Vascular Center Semmelweis University Budapest Hungary
IDIBAPS Dept of Cardiology Hospital Clinic Barcelona Spain
Med Klinik und Poliklinik 1 Technische Universität München Klinikum rechts der Isar Munich Germany
Medical Research Center Oulu University Hospital Finland; University of Oulu Finland
National Heart and Lung Institute Imperial College London United Kingdom
Slovak Medical University Bratislava Slovakia; NUSCH Bratislava Slovakia
References provided by Crossref.org
