The 2017 World Health Organization (WHO) classification proposes to type and subtype primary adenohypophyseal tumours according to their cell lineages with the aim to establish more uniform tumour groups. The definition of atypical adenoma was removed in favour of high-risk adenoma, and the assessment of proliferative activity and invasion was recommended to diagnose aggressive tumours. Recently, the International Pituitary Pathology Club proposed to replace adenoma with the term of pituitary neuroendocrine tumour (PitNET) to better reflect the similarities between adenohypophyseal and neuroendocrine tumours of other organs. The European Pituitary Pathology Group (EPPG) endorses this terminology and develops practical recommendations for standardised reports of PitNETs that are addressed to histo- and neuropathologists. This brief report presents the results of EPPG's consensus for the reporting of PitNETs and proposes a diagnostic algorithm.

1st Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary

Centre de Pathologie et de Neuropathologie Est Groupement Hospitalier Est Hospices Civils de Lyon Bron France

Centre de Recherche en Cancérologie de Lyon INSERM U1052 CNRS UMR5286 Université de Lyon Lyon France

Department of Biomedical and Neuromuscular Sciences Section of Anatomic Pathology 'M Malpighi' at Bellaria Hospital University of Bologna Bologna Italy

Department of Biotechnological and Applied Clinical Sciences University of L'Aquila L'Aquila Italy

Department of Diagnostics and Public Health University of Verona Verona Italy

Department of Endocrinology CHU de Liège University of Liège Sart Tilman B35 4000 Liège Belgium

Department of Fundamental Pathomorphology Endocrine Research Center Ministry of Health of Russia Moscow Russia

Department of Histology Pharmacy Sciences and Technology of Tirgu Mures University of Medicine Târgu Mureș Romania

Department of Medicine DIMED Surgical Pathology and Cytopathology Unit University Hospital of Padova Padova Italy

Department of Molecular and Translational Medicine University of Brescia Brescia Italy

Department of Pathological Cytology and Anatomy Foch Hospital 40 rue Worth 92151 Suresnes France

Department of Pathology Rizzoli Institute Bologna Italy

Division of Neuroscience and Experimental Psychology School of Biological Sciences Faculty of Biology Medicine and Health University of Manchester Manchester UK

Endocrinology Unit Department of Biomedical Sciences Humanitas University and Humanitas Research Hospital Rozzano Italy

Faculté de Médecine Lyon Est F 69372 Lyon France

INSERM U1016 CNRS UMR 8104 Cochin Institute Paris Descartes University 24 rue du faubourg Saint Jacques 75014 Paris France

Institute of Neuropathology University Medical Center Hamburg Eppendorf Hamburg Germany

Medizinische Klinik und Poliklinik 4 Klinikum der Universität München Ludwig Maximilians Universität München Munich Germany

Neuromed Institute IRCCS Pozzilli Italy

Nuffield Department of Clinical Neurosciences University of Oxford Oxford OX3 9DU UK

Pituitary Unit Center for the Diagnosis and Treatment of Hypothalamic and Pituitary Diseases IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy

The Fingerland Department of Pathology University Hospital and Faculty of Medicine Hradec Kralove Charles University Sokolska 581 500 05 Hradec Kralove Czech Republic

Unit of Pathology Department of Medicine and Surgery University of Insubria Varese Italy

Université de Lyon 1 Université de Lyon F 69000 Lyon France

Zobrazit více v PubMed

Eur J Endocrinol. 2015 Jun;172(6):791-801 PubMed

Arch Pathol Lab Med. 2015 Mar;139(3):356-72 PubMed

Mod Pathol. 2018 Dec;31(12):1770-1786 PubMed

Nat Rev Endocrinol. 2018 Dec;14(12):705-720 PubMed

Acta Neuropathol. 2013 Jul;126(1):123-35 PubMed

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3368-3374 PubMed

Pituitary. 2017 Feb;20(1):10-21 PubMed

Virchows Arch. 2018 Mar;472(3):341-349 PubMed

Eur J Endocrinol. 2018 Jun;178(6):C7-C9 PubMed

J Clin Endocrinol Metab. 2018 Dec 21;:null PubMed

Eur J Endocrinol. 2019 Feb 1;180(2):127-134 PubMed

Endocr Relat Cancer. 2017 Apr;24(4):C5-C8 PubMed

Pituitary. 2017 Oct;20(5):489-498 PubMed

Eur J Endocrinol. 2018 Jan;178(1):G1-G24 PubMed

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2473-2489 PubMed

Arch Pathol Lab Med. 2017 Jan;141(1):104-112 PubMed

J Clin Endocrinol Metab. 2015 Aug;100(8):3165-71 PubMed

Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly