Hemocompatibility is an essential prerequisite for the application of materials in the field of biomedicine and biosensing. In addition, mixed ionic and electronic conductivity of conducting polymers is an advantageous property for these applications. Heparin-like materials containing sulfate, sulfamic, and carboxylic groups may have an anticoagulation effect. Therefore, sodium dodecylbenzenesulfonate, 2-aminoethane-1-sulfonic acid and N-(2-acetamido)-2-aminoethanesulfonic acid were used for modification of the representative of conducting polymers, polyaniline, and the resulting products were studied in the context of interactions with human blood. The anticoagulation activity was then correlated to surface energy and conductivity of the materials. Results show that anticoagulation activity is highly affected by the presence of suitable functional groups originating from the used heparin-like substances, and by the properties of polyaniline polymer itself.

Centre of Polymer Systems Tomas Bata University in Zlín 760 01 Zlín Czech Republic

Department of Hematology Tomas Bata Regional Hospital in Zlín 762 75 Zlín Czech Republic

Faculty of Humanities Tomas Bata University in Zlín 760 01 Zlín Czech Republic

Faculty of Technology Tomas Bata University in Zlín 760 01 Zlín Czech Republic

Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic 162 06 Prague 6 Czech Republic

Jožef Stefan Institute Jamova 39 Ljubljana 1000 Slovenia

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Polymer Biointerfaces