Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome
Language English Country Sweden Media print
Document type Journal Article
PubMed
31785215
PII: NEL400219A07
Knihovny.cz E-resources
- MeSH
- Biomarkers analysis blood MeSH
- C-Reactive Protein analysis metabolism MeSH
- Adult MeSH
- Interleukin-6 analysis blood MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Monitoring, Physiologic methods MeSH
- Sleep Apnea, Obstructive blood diagnosis therapy MeSH
- Prospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Serum Amyloid P-Component analysis metabolism MeSH
- Case-Control Studies MeSH
- Severity of Illness Index MeSH
- Sleep Apnea Syndromes blood diagnosis therapy MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Interleukin-6 MeSH
- PTX3 protein MeSH Browser
- Serum Amyloid P-Component MeSH
OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 serum levels and obstru-ctive sleep apnea syndrome. DESIGN: Prospective cohort study. MATERIAL AND METHODS: A group of 146 patients with middle to severe obstructive sleep apnea syndrome (OSAS) were monitored, and the results were compared with the results from a control group of healthy individuals. RESULTS: We assessed serum levels of the following biomarkers: CRP, PTX-3, IL6, hsTnI, BNP, and galectin-3. PTX-3 serum levels were statistically significantly higher (p<0.0001) in patients with OSAS, compared to controls. Statistical results related to the other biomarkers did not suggest any clinical value. ROC analysis showed that PTX-3 might be able to distinguish patients with OSAS from healthy individuals (AUC=7438). CONCLUSION: The elevation of PTX-3 serum levels is significantly associated with middle to severe obstructive sleep apnea syndrome. The PTX-3 biomarker appears to be a promising alternative method for sleep apnea syndrome investigations.
