Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy - Experimental Study
Jazyk angličtina Země Řecko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
31810926
DOI
10.21873/anticanres.13876
PII: 39/12/6603
Knihovny.cz E-zdroje
- Klíčová slova
- Pancreaticoduodenectomy, allogeneic grafts, computer blood flow simulation, portal vein haemodynamics, portal vein reconstruction,
- MeSH
- alografty MeSH
- anastomóza chirurgická metody MeSH
- hemodynamika MeSH
- léčba šetřící orgány MeSH
- mrtvola MeSH
- odběr tkání a orgánů MeSH
- pankreatoduodenektomie * MeSH
- počítačová simulace * MeSH
- pooperační komplikace etiologie MeSH
- prasata MeSH
- pylorus MeSH
- regionální krevní průtok MeSH
- ultrasonografie MeSH
- velikost orgánu MeSH
- vena cava inferior anatomie a histologie diagnostické zobrazování fyziologie transplantace MeSH
- vena portae anatomie a histologie diagnostické zobrazování fyziologie chirurgie MeSH
- zákroky plastické chirurgie metody MeSH
- žilní trombóza etiologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
BACKGROUND: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. MATERIALS AND METHODS: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. RESULTS: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. CONCLUSION: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Anatomy Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Mechanics Faculty of Applied Sciences University of West Bohemia Pilsen Czech Republic
Department of Medical Imaging Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Surgery Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
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