Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
31928054
DOI
10.33549/physiolres.934347
PII: 934347
Knihovny.cz E-zdroje
- MeSH
- 2-amino-5-fosfonovalerát analogy a deriváty MeSH
- AMPA receptory antagonisté a inhibitory MeSH
- benzodiazepiny MeSH
- chinoxaliny MeSH
- dizocilpinmaleát MeSH
- homocystein analogy a deriváty chemie toxicita MeSH
- potkani Wistar MeSH
- receptory N-methyl-D-aspartátu antagonisté a inhibitory MeSH
- stereoizomerie MeSH
- záchvaty chemicky indukované MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 2-amino-4-methyl-5-phosphono-3-pentenoic acid MeSH Prohlížeč
- 2-amino-5-fosfonovalerát MeSH
- 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline MeSH Prohlížeč
- AMPA receptory MeSH
- benzodiazepiny MeSH
- chinoxaliny MeSH
- dizocilpinmaleát MeSH
- GYKI 52466 MeSH Prohlížeč
- homocysteic acid MeSH Prohlížeč
- homocystein MeSH
- receptory N-methyl-D-aspartátu MeSH
Mechanism of ictogenesis of D- and L-stereroisomers of homocysteic acid was studied in 12-day-old rats by means of antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. There was no qualitative difference between the two stereoisomers in generation of emprosthotonic (flexion) as well as generalized tonic-clonic seizures. Moderate differences were observed in the first, nonconvulsive effects of the two isomers. As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures.
Citace poskytuje Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
