Iron-oxide minerals in the human tissues
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31970541
DOI
10.1007/s10534-020-00232-6
PII: 10.1007/s10534-020-00232-6
Knihovny.cz E-resources
- Keywords
- Biomineralization, Ferritin, Human tissues, Iron oxides,
- MeSH
- Ferritins metabolism MeSH
- Humans MeSH
- Brain metabolism MeSH
- Neurodegenerative Diseases metabolism pathology MeSH
- Oxides metabolism MeSH
- Iron metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ferritins MeSH
- Oxides MeSH
- Iron MeSH
Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic; therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.
References provided by Crossref.org
Formation of gadolinium-ferritin from clinical magnetic resonance contrast agents
