Transition metal carbides, known as MXenes, are generated via the selective etching of "A" layers from their layered, ternary parent compounds, MAX phases, where M corresponds to early d-transition metal, A being a main group sp-element from either Group 13 or 14 and carbon or nitrogen being denoted by X. MXenes are being recognized as a new and uprising class of 2D materials with extraordinary physical and electrochemical properties. The huge specific surface area and outstanding electrical conductivity of MXenes, make them ideal candidates for sensing and energy applications. Herein, we demonstrated the successful incorporation of pristine MXene, Ti3C2 produced via HF etching and subsequent delamination with TBAOH, as a transducer platform toward the development of a second generation electrochemical glucose biosensor. Chronoamperometric studies demonstrate that the proposed biosensing system exhibits high selectivity and excellent electrocatalytic activity toward the detection of glucose, spanning over wide linear ranges of 50-27 750 μM and possess a low limit of detection of 23.0 μM. The findings reported in this study conceptually proves the probable applications of pristine MXenes toward the field of biosensors and pave ways for the future developments of highly selective and sensitive electrochemical biosensors for biomedical and food sampling applications.

Center for Advanced Functional Nanorobots Department of Inorganic Chemistry Faculty of Chemical Technology University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Dejvice Czech Republic

Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei ro Seodaemun gu Seoul 03722 Korea

Department of Inorganic Chemistry University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Dejvice Czech Republic

Department of Medical Research China Medical University Hospital China Medical University No 91 Hsueh Shih Road Taichung Taiwan

Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371

Future Energy and Innovation Laboratory Central European Institute of Technology Brno University of Technology Purkyňova 656 123 Brno CZ 616 00 Czech Republic

Institute of Energy and Climate Research Forschungszentrum Jülich 52425 Jülich Germany

NTU Institute for Health Technologies Interdisciplinary Graduate School Nanyang Technological University 50 Nanyang Drive 637553 Singapore

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Cellulose Triacetate-Based Mixed-Matrix Membranes with MXene 2D Filler-CO2/CH4 Separation Performance and Comparison with TiO2-Based 1D and 0D Fillers

Telemedicine platform for health assessment remotely by an integrated nanoarchitectonics FePS3/rGO and Ti3C2-based wearable device