Integration of Cryo-EM Model Building Software in Scipion
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cryoelectron Microscopy MeSH
- Image Processing, Computer-Assisted * MeSH
- Workflow MeSH
- Software * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Advances in cryo-electron microscopy (cryo-EM) have made it possible to obtain structures of large biological macromolecules at near-atomic resolution. This "resolution revolution" has encouraged the use and development of modeling tools able to produce high-quality atomic models from cryo-EM density maps. Unfortunately, many practical problems appear when combining different packages in the same processing workflow, which make difficult the use of these tools by non-experts and, therefore, reduce their utility. We present here a major extension of the image processing framework Scipion that provides inter-package integration in the model building area and full tracking of the complete workflow, from image processing to structure validation.
CNB CSIC C Darwin 3 28049 Madrid Spain
Institute of Computer Science Masaryk University Botanická 68a 60200 Brno Czech Republic
References provided by Crossref.org
Scipion3: A workflow engine for cryo-electron microscopy image processing and structural biology
ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation
Advances in Xmipp for Cryo-Electron Microscopy: From Xmipp to Scipion
